Neuroanatomical Correlates of Memory Strategies in Rats

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dc.contributor.authorBalci, Aysu
dc.contributor.authorCankurtaran, Buse Pinar
dc.contributor.authorAkyel, Aybuke
dc.contributor.authorArikan, Kutluk Bilge
dc.contributor.authorUnal, Bengi
dc.contributor.authorUnal, Cagri Temucin
dc.date.accessioned2025-05-29T02:58:09Z
dc.date.available2025-05-29T02:58:09Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNavigation incorporates a continuum of strategies, where the allocentric strategy relies on relationships between environmental landmarks resulting in a cognitive map, and the egocentric strategy revolves around the body position and stimulus response chains with the body as a reference. Although multiple brain regions contribute to navigation, the hippocampus dominates allocentric navigation, whereas the striatum is key for egocentric navigation. Neuromodulators, such as dopamine and acetylcholine, regulate both the hippocampus and striatum to influence behavior, yet their influence on navigational strategy has not been determined. Interindividual differences in strategy preference are known to exist. Building on these pre-existing interindividual differences, this study explored the neuroanatomical underpinnings on navigational strategy variations in rats through a dual-solution T-maze and immunocytochemistry. Surprisingly, interindividual variations eluded explanation through the density of cholinergic neurons supplying acetylcholine to the hippocampus and striatum. Similarly, the soma morphologies of these neurons exhibited no discernible differences. Dopaminergic cell densities in the ventral tegmental area (VTA), projecting to the hippocampus, and substantia nigra pars compacta (SNpc), projecting to the striatum, failed to account for individual variations as well. Nevertheless, allocentric rats displayed higher VTA/SNpc dopamine neuron fusiformity indexes, potentially contributing to computational distinctions underlying interindividual variations in navigation strategies. This study delves into potential explanations and charts promising avenues for future research. A graphical abstract summarizing the main findings of this study is provided.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) [218K570]
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkiye (TUBITAK) with the (Grant 218K570) to Cagri Temucin Unal, Bengi Unal, and Kutluk Bilge Arikan.
dc.identifier.doi10.1002/syn.70015
dc.identifier.issn0887-4476
dc.identifier.issn1098-2396
dc.identifier.issue3
dc.identifier.pmid40172864
dc.identifier.scopus2-s2.0-105002064700
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1002/syn.70015
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30290
dc.identifier.volume79
dc.identifier.wosWOS:001489858400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofSynapse-Structure Function Connectivity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectacetylcholine
dc.subjectdopamine
dc.subjectmedial septum
dc.subjectmorphology
dc.subjectmultiple memory systems
dc.subjectstriatum
dc.titleNeuroanatomical Correlates of Memory Strategies in Rats
dc.typeArticle

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