Use of Chitosan-Coated Conductive Copper/Nanoparticle Polymer in Drug Delivery System by Encapsulation Method

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dc.authoridŞenol Bahçeci, Dilek / 0000-0001-7854-0419
dc.authoridKocaeren, Aysel Aydın / 0000-0003-4113-0517
dc.authoridDemir, Neslihan / 0000-0002-2347-8344
dc.contributor.authorŞenol Bahçeci, Dilek
dc.contributor.authorKocaeren, Aysel Aydın
dc.contributor.authorDemir, Neslihan
dc.contributor.authorDalgıç, Büşra
dc.date.accessioned2025-05-29T02:57:40Z
dc.date.available2025-05-29T02:57:40Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, 4-amino-3-hydroxy-1-naphthalenesulfonic acid was polymerized by the oxidative polymerization method. Copper nanoparticles of the synthesized PSa were prepared with copper sulfate solution. Structural analysis of the synthesized compounds were determined by FTIR, H-1 NMR and C-13 NMR measurements. Its optical properties were measured by UV-Vis spectrophotometer, thermal analysis by Thermogravimetric Analysis (TG) device, morphological properties by scanning electron microscope (SEM) device, and crystallographic properties by X-ray Diffraction (XRD) device. Additionally, HOMO-LUMO band gaps were calculated by determining oxidation-reduction peak potential values with the Cyclic Voltammetry (CV) device. Since CuNPs@PSa shows very good antimicrobial properties against some yeasts and bacteria, its usability in drug release was investigated. For this, Ch-CuNPs@PSa encapsulation study was carried out by coating CuNPs@PSa with chitosan (Ch). Encapsulation efficiency, loading capacity, and in vitro release kinetics were calculated. As a result, it was observed that chitosan encapsulation increased the antimicrobial effect against bacteria and yeasts and achieved the release in a controlled manner. It has been determined that Ch-CuNPs@PSa can be used in drug delivery systems as it has an Encapsulation Efficiency (EE) of 98.70%, a Loading Capacity (LC) of 78.96% and a cumulative release of 98.84%. In this case, it can be said that the obtained Ch-CuNPs@PSa can be evaluated as effective in drug release studies.
dc.identifier.doi10.1134/S156009042560007X
dc.identifier.endpage661
dc.identifier.issn1560-0904
dc.identifier.issn1555-6123
dc.identifier.issue5
dc.identifier.scopus2-s2.0-105001072166
dc.identifier.scopusqualityQ3
dc.identifier.startpage649
dc.identifier.urihttps://doi.org/10.1134/S156009042560007X
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30128
dc.identifier.volume66
dc.identifier.wosWOS:001426401200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMaik Nauka/Interperiodica/Springer
dc.relation.ispartofPolymer Science Series B
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectAminobenzene Sulfonic-Acid
dc.subjectCopper Nanoparticles
dc.subjectElectrochemical Oxidation
dc.subjectElectrical-Conductivity
dc.subjectOptical-Properties
dc.subjectStability
dc.titleUse of Chitosan-Coated Conductive Copper/Nanoparticle Polymer in Drug Delivery System by Encapsulation Method
dc.typeArticle

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