Chemical Characterization, Antibacterial, Antioxidant, and Cytotoxic Activity of Some Essential Oils Against Strains Causing Acne

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dc.contributor.authorAltun, Mehzat
dc.contributor.authorYildirim, Nuray
dc.contributor.authorYapici, Binnur M.
dc.date.accessioned2025-01-27T21:01:41Z
dc.date.available2025-01-27T21:01:41Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe potential of essential oils (EOs) as alternatives to antibiotics for the treatment of acne vulgaris is an area of growing interest due to increasing antibacterial resistance. This study aimed to determine antimicrobial efficacy, chemical profile, and the antioxidant and cytotoxic potential of EOs. Antimicrobial activity was assessed using disc diffusion and minimum inhibitory concentration (MIC) assays against Staphylococcus epidermidis ATCC 12228 and Cutibacterium acnes ATCC 6919. The phytochemical content of oils was determined by gas chromatography/mass spectrometry. The 2,2-diphenyl-1-picrylhydrazyl and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods were used to detect antioxidant properties and cell viability, respectively. Limonene, p-cymene, linalool, 1.8-cineole, & beta;-santalol, cinnamaldehyde, carvacrol, and eucalyptol were the major components of lemon, tea tree, lavender, laurel, sandalwood, cinnamon, oregano, and eucalyptus EOs, respectively. The MIC/minimum bactericidal concentration values were between 0.03125% and 32% (v/v). Binary combinations of cinnamon/lavender and cinnamon/sandalwood exhibited synergism against both bacteria. The Cinnamomum verum showed the greatest antioxidant activity (IC50: 35.08 & mu;g/ml). The cytotoxic activity of EOs at concentrations between 2% and 0.0625% was evaluated against a mouse fibroblast (NIH 3T3) cell line. In vitro test results revealed that antibacterial effective EOs may be used in development of topical acne therapy after in vivo and clinical trials are carried out.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Unit [FBA-2020-3412]
dc.description.sponsorshipThis study was supported by the Canakkale Onsekiz Mart University Scientific Research Projects Unit (Project ID: FBA-2020-3412) .
dc.identifier.endpage30
dc.identifier.issn1525-7886
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85171425803
dc.identifier.scopusqualityQ3
dc.identifier.startpage14
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27148
dc.identifier.volume74
dc.identifier.wosWOS:001072395700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSoc Cosmetic Chemists
dc.relation.ispartofJournal of Cosmetic Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectTea-Tree Oil
dc.subjectAntimicrobial Activity
dc.subjectEucalyptus-Globulus
dc.subjectExtracts
dc.subjectCapacity
dc.subjectEfficacy
dc.titleChemical Characterization, Antibacterial, Antioxidant, and Cytotoxic Activity of Some Essential Oils Against Strains Causing Acne
dc.typeArticle

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