Chemical Characterization, Antibacterial, Antioxidant, and Cytotoxic Activity of Some Essential Oils Against Strains Causing Acne
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Cosmetic Chemists
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The potential of essential oils (EOs) as alternatives to antibiotics for the treatment of acne vulgaris is an area of growing interest due to increasing antibacterial resistance. This study aimed to determine antimicrobial efficacy, chemical profile, and the antioxidant and cytotoxic potential of EOs. Antimicrobial activity was assessed using disc diffusion and minimum inhibitory concentration (MIC) assays against Staphylococcus epidermidis ATCC 12228 and Cutibacterium acnes ATCC 6919. The phytochemical content of oils was determined by gas chromatography/mass spectrometry. The 2,2-diphenyl-1-picrylhydrazyl and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods were used to detect antioxidant properties and cell viability, respectively. Limonene, p-cymene, linalool, 1.8-cineole, & beta;-santalol, cinnamaldehyde, carvacrol, and eucalyptol were the major components of lemon, tea tree, lavender, laurel, sandalwood, cinnamon, oregano, and eucalyptus EOs, respectively. The MIC/minimum bactericidal concentration values were between 0.03125% and 32% (v/v). Binary combinations of cinnamon/lavender and cinnamon/sandalwood exhibited synergism against both bacteria. The Cinnamomum verum showed the greatest antioxidant activity (IC50: 35.08 & mu;g/ml). The cytotoxic activity of EOs at concentrations between 2% and 0.0625% was evaluated against a mouse fibroblast (NIH 3T3) cell line. In vitro test results revealed that antibacterial effective EOs may be used in development of topical acne therapy after in vivo and clinical trials are carried out.
Açıklama
Anahtar Kelimeler
Tea-Tree Oil, Antimicrobial Activity, Eucalyptus-Globulus, Extracts, Capacity, Efficacy
Kaynak
Journal of Cosmetic Science
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
74
Sayı
1
