Paving Luteolin Therapeutic Potentialities and Agro-FoodPharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

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dc.authorid0000-0001-7069-3250en_US
dc.authorid0000-0001-8989-8045en_US
dc.authorid0000-0002-1740-4867en_US
dc.authorscopusid57210746729en_US
dc.authorscopusid57211689507en_US
dc.authorscopusid22136607900en_US
dc.authorwosidCBN-8109-2022en_US
dc.authorwosidGSE-3886-2022en_US
dc.authorwosidEBN-0588-2022en_US
dc.contributor.authorTaheri, Yasaman
dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorAntika, Gizem
dc.contributor.authorYılmaz, Yakup Berkay
dc.contributor.authorBoyuneğmez Tümer, Tuğba
dc.contributor.authorAbuhamdah, Sawsan
dc.date.accessioned2022-12-31T09:25:13Z
dc.date.available2022-12-31T09:25:13Z
dc.date.issued2021en_US
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Biyomoleküler Bilimler Ana Bilim Dalı
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Moleküler Biyoloji ve Genetik Ana Bilim Dalı
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractLuteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, antiviral, and anti-inflammatory effects, and as a consequence, various clinical trials have been designed to investigate the therapeutic potential of luteolin in humans. However, luteolin has a very limited bioavailability, which consequently affects its biological properties and efficacy. Several drug delivery strategies have been developed to raise its bioavailability, with nanoformulations and lipid carriers, such as liposomes, being the most intensively explored. Pharmacological potential of luteolin in various disorders has also been underlined, but to some of them, the exact mechanism is still poorly understood. Given the great potential of this natural antioxidant in health, this review is aimed at providing an extensive overview on the in vivo pharmacological action of luteolin and at stressing the main features related to its bioavailability, absorption, and metabolism, while essential steps determine its absolute health benefits and safety profiles. In addition, despite the scarcity of studies on luteolin bioavailability, the different drug delivery formulations developed to increase its bioavailability are also listed here.en_US
dc.identifier.citationTaheri, Y., Sharifi-Rad, J., Antika, G., Yılmaz, Y. B., Tumer, T. B., Abuhamdah, S., … Cho, W. C. (2021). Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits. Oxidative Medicine and Cellular Longevity, 2021, 1–20. https://doi.org/10.1155/2021/1987588en_US
dc.identifier.doi10.1155/2021/1987588
dc.identifier.endpage20en_US
dc.identifier.issn1942-0900
dc.identifier.issn1942-0994
dc.identifier.pmid34594472
dc.identifier.scopus2-s2.0-85116639417
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1155/2021/1987588
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3761
dc.identifier.volume2021en_US
dc.identifier.wosWOS:000703531200003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAntika, Gizem
dc.institutionauthorYılmaz, Yakup Berkay
dc.institutionauthorBoyuneğmez Tümer, Tuğba
dc.language.isoen
dc.publisherHindawien_US
dc.relation.ispartofOxidative Medicine and Cellular Longevityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin Resistanceen_US
dc.subjectUdp-Glucuronosyltransferasesen_US
dc.subjectIschemia/Reperfusion In Juryen_US
dc.subjectIntestinal-Absorptionen_US
dc.subjectPhospholipid complexen_US
dc.subjectOxidative Stressen_US
dc.subjectAdipose-Tissueen_US
dc.subjectAnimal Modelen_US
dc.subjectMiceen_US
dc.subjectMetabolismen_US
dc.titlePaving Luteolin Therapeutic Potentialities and Agro-FoodPharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits
dc.typeReview Article

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