Paving Luteolin Therapeutic Potentialities and Agro-FoodPharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hindawi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, antiviral, and anti-inflammatory effects, and as a consequence, various clinical trials have been designed to investigate the therapeutic potential of luteolin in humans. However, luteolin has a very limited bioavailability, which consequently affects its biological properties and efficacy. Several drug delivery strategies have been developed to raise its bioavailability, with nanoformulations and lipid carriers, such as liposomes, being the most intensively explored. Pharmacological potential of luteolin in various disorders has also been underlined, but to some of them, the exact mechanism is still poorly understood. Given the great potential of this natural antioxidant in health, this review is aimed at providing an extensive overview on the in vivo pharmacological action of luteolin and at stressing the main features related to its bioavailability, absorption, and metabolism, while essential steps determine its absolute health benefits and safety profiles. In addition, despite the scarcity of studies on luteolin bioavailability, the different drug delivery formulations developed to increase its bioavailability are also listed here.
Açıklama
Anahtar Kelimeler
Insulin Resistance, Udp-Glucuronosyltransferases, Ischemia/Reperfusion In Jury, Intestinal-Absorption, Phospholipid complex, Oxidative Stress, Adipose-Tissue, Animal Model, Mice, Metabolism
Kaynak
Oxidative Medicine and Cellular Longevity
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
2021
Sayı
Künye
Taheri, Y., Sharifi-Rad, J., Antika, G., Yılmaz, Y. B., Tumer, T. B., Abuhamdah, S., … Cho, W. C. (2021). Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits. Oxidative Medicine and Cellular Longevity, 2021, 1–20. https://doi.org/10.1155/2021/1987588
