A new candidate for wound dressing materials: s-IPN hydrogel-based highly elastic and pH-sensitive drug delivery system containing pectin and vinyl phosphonic acid

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dc.authoridÖzay, Özgür/0000-0001-6589-9844
dc.contributor.authorSeref, Elif
dc.contributor.authorIlgin, Pinar
dc.contributor.authorÖzay, Özgür
dc.contributor.authorOzay, Hava
dc.date.accessioned2025-01-27T20:54:33Z
dc.date.available2025-01-27T20:54:33Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, we developed pH-sensitive semi-interpenetrating network (s-IPN) hydrogels, composed of pectin, 2hydroxyethyl methacrylate (HEMA), and vinyl phosphonic acid (VPA) using N,N'-methylene bis(acrylamide) (MBA) as a cross-linker with the free-radical polymerization method. The formation of s-IPNs was confirmed by FTIR studies. SEM images showed the addition of VPA to the polymeric matrix of s-IPN hydrogels formed additional microporous structures within the hydrogel network. The s-IPN hydrogel had perfect mechanical features like stretchability, compressibility and elasticity. Additionally, the swelling behavior of s-IPN hydrogels in deionized water and solutions with diverse pH was assessed. To research use as a controlled drug delivery material, the hydrogel was loaded with cimetidine and trimethoprim. At pH 7.2, the in vitro drug release profile was observed and nearly 60 % of the drugs were released from s-IPN hydrogel within 10 h. Additionally, the most appropriate kinetic release model was Higuchi, followed by Korsmeyer-Peppas. Finally, silver sulfadiazine (SSD) was added to s-IPN hydrogel for use as a smart wound dressing material. Antimicrobial analysis of the SSDloaded s-IPN hydrogel found it had antimicrobial features, inducing 15, 17 and 23 mm inhibition zones against Staphylococcus aureus (gram-positive), Escherichia coli (gram -negative) and Candida albicans (fungus) microorganisms, respectively. In light of the obtained results, based on being easily shapable with appropriate mechanical and physical features, pectin/p(HEMA-co-VPA) and pectin/p(HEMA-co-VPA)@SSD s-IPN hydrogels are potential candidates for use as controlled drug delivery and wound dressing materials in the biomedical field.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Coordination Unit (COMU BAP); [FBA-2023-4273]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University Scientific Research Coordination Unit (COMU BAP) , Project number: FBA-2023-4273. The authors thank Associate Professor Yavuz Emre Arslan for mechanical compression analysis.
dc.identifier.doi10.1016/j.eurpolymj.2024.112824
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85185287238
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2024.112824
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26104
dc.identifier.volume207
dc.identifier.wosWOS:001187191000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofEuropean Polymer Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSilver sulfadiazine
dc.subjectHydrogel
dc.subjectVinyl phosphonic acid
dc.subjectDrug-delivery
dc.titleA new candidate for wound dressing materials: s-IPN hydrogel-based highly elastic and pH-sensitive drug delivery system containing pectin and vinyl phosphonic acid
dc.typeArticle

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