Novel hydrogels based on crosslinked chitosan with formyl-phosphazene using Schiff-base reaction

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dc.authorid0000-0002-4184-7801en_US
dc.authorid0000-0001-7071-0575en_US
dc.authorid0000-0001-6589-9844en_US
dc.authorscopusid35102910700en_US
dc.authorscopusid36053000200en_US
dc.authorscopusid23973597600en_US
dc.authorwosidCDG-4591-2022en_US
dc.authorwosidDXD-6855-2022en_US
dc.authorwosidDND-2034-2022en_US
dc.contributor.authorÖzay, Hava
dc.contributor.authorIlgın, Pınar
dc.contributor.authorÖzay, Özgur
dc.date.accessioned2023-05-16T06:26:44Z
dc.date.available2023-05-16T06:26:44Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.departmentMeslek Yüksekokulları, Lapseki Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü
dc.description.abstractIn this study, chitosan, an aminopolysaccharide, was reacted with phosphazene-derived crosslinker by Schiff-base reaction to yield crosslinked-chitosan hydrogel. Here, hexakis(4-formylphenoxy)cyclotriphosphazene was used as a novel crosslinker agent with six reactive functional groups allowing the formation of bridges between polymeric chains. Amoxicillin, known effective bacteriostatic treatment, was used as a model drug to test the drug-carrying capacity of the gel and the antibacterial activity. Further, the acid-catalyzed aqueous degradation behavior of hydrogels was assessed in vitro. In conclusion, it is predicted that this newly obtained biodegradable hydrogel may have the potential to be used as a promising drug-carrying material in biomedical application fields.en_US
dc.identifier.citationÖzay, H., Ilgın, P., & Özay, O. (2021). Novel hydrogels based on crosslinked chitosan with formyl-phosphazene using schiff-base reaction. International Journal of Polymeric Materials and Polymeric Biomaterials, 70(4), 246-255. doi:10.1080/00914037.2019.1706514en_US
dc.identifier.doi10.1080/00914037.2019.1706514
dc.identifier.endpage255en_US
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85077399528
dc.identifier.startpage246en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2019.1706514
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4159
dc.identifier.volume70en_US
dc.identifier.wosWOS:000504603200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzay, Hava
dc.institutionauthorIlgın, Pınar
dc.institutionauthorÖzay, Özgur
dc.language.isoen
dc.publisherTaylor & Francis Group, LLCen_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectDrug releaseen_US
dc.subjectHydrogelen_US
dc.subjectPhosphazeneen_US
dc.subjectSchiff-baseen_US
dc.titleNovel hydrogels based on crosslinked chitosan with formyl-phosphazene using Schiff-base reaction
dc.typeArticle

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