Novel hydrogels based on crosslinked chitosan with formyl-phosphazene using Schiff-base reaction
Yükleniyor...
Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Group, LLC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, chitosan, an aminopolysaccharide, was reacted with phosphazene-derived crosslinker by Schiff-base reaction to yield crosslinked-chitosan hydrogel. Here, hexakis(4-formylphenoxy)cyclotriphosphazene was used as a novel crosslinker agent with six reactive functional groups allowing the formation of bridges between polymeric chains. Amoxicillin, known effective bacteriostatic treatment, was used as a model drug to test the drug-carrying capacity of the gel and the antibacterial activity. Further, the acid-catalyzed aqueous degradation behavior of hydrogels was assessed in vitro. In conclusion, it is predicted that this newly obtained biodegradable hydrogel may have the potential to be used as a promising drug-carrying material in biomedical application fields.
Açıklama
Anahtar Kelimeler
Chitosan, Drug release, Hydrogel, Phosphazene, Schiff-base
Kaynak
International Journal of Polymeric Materials and Polymeric Biomaterials
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
70
Sayı
4
Künye
Özay, H., Ilgın, P., & Özay, O. (2021). Novel hydrogels based on crosslinked chitosan with formyl-phosphazene using schiff-base reaction. International Journal of Polymeric Materials and Polymeric Biomaterials, 70(4), 246-255. doi:10.1080/00914037.2019.1706514
