A Pharmacological Perspective on Plant?derived Bioactive Molecules for Epilepsy

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dc.authorid0000-0002-1740-4867en_US
dc.authorid-en_US
dc.authorscopusid22136607900en_US
dc.authorscopusid57202999400en_US
dc.authorwosidEBN-0588-2022en_US
dc.authorwosidFEB-2029-2022en_US
dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorQuispe, Cristina
dc.contributor.authorHerrera-Bravo, Jesus
dc.contributor.authorMartorell, Miquel
dc.contributor.authorSharopov, Farukh
dc.contributor.authorBoyuneğmez Tümer, Tuğba
dc.contributor.authorKurt, Begüm
dc.contributor.authorLankatillake, Chintha
dc.contributor.authorDocea, Anca Oana
dc.contributor.authorMoreira, Ana Catarina
dc.contributor.authorDias, Daniel A.
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorLobine, Devina
dc.contributor.authorCruz-Martins, Natalia
dc.contributor.authorKumar, Manoj
dc.contributor.authorCalina, Daniela
dc.date.accessioned2022-08-04T13:16:10Z
dc.date.available2022-08-04T13:16:10Z
dc.date.issued2021en_US
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Biyomoleküler Bilimler Ana Bilim Dalı
dc.description.abstractEpilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifcally proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that favonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant efect, pharmacological models, seizure-inducing factors and response, efective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.en_US
dc.identifier.citationSharifi-Rad, J., Quispe, C., Herrera-Bravo, J., Martorell, M., Sharopov, F., Tumer, T. B., … Calina, D. (2021). A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research, 46(9), 2205–2225. https://doi.org/10.1007/s11064-021-03376-0en_US
dc.identifier.doi10.1007/s11064-021-03376-0
dc.identifier.endpage2225en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue9en_US
dc.identifier.pmid34120291
dc.identifier.scopus2-s2.0-85107849326
dc.identifier.startpage2205en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-021-03376-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3648
dc.identifier.volume46en_US
dc.identifier.wosWOS:000660805400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBoyuneğmez Tümer, Tuğba
dc.institutionauthorKurt, Begüm
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpilepsyen_US
dc.subjectNatural Compoundsen_US
dc.subjectHerbal Medicinesen_US
dc.subjectAnticonvulsanten_US
dc.subjectMolecular Mechanismsen_US
dc.subjectPharmacological Modelsen_US
dc.titleA Pharmacological Perspective on Plant?derived Bioactive Molecules for Epilepsy
dc.typeArticle

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