A Pharmacological Perspective on Plant?derived Bioactive Molecules for Epilepsy
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose
of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived
bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria.
Natural compounds/herbs with scientifcally proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that favonoids, alkaloids and terpenoids may have anticonvulsant mechanisms
similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant efect, pharmacological
models, seizure-inducing factors and response, efective dose were also analyzed and discussed. The results of in vitro and
in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived
bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural
anticonvulsant drugs.
Açıklama
Anahtar Kelimeler
Epilepsy, Natural Compounds, Herbal Medicines, Anticonvulsant, Molecular Mechanisms, Pharmacological Models
Kaynak
Neurochemical Research
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
46
Sayı
9
Künye
Sharifi-Rad, J., Quispe, C., Herrera-Bravo, J., Martorell, M., Sharopov, F., Tumer, T. B., … Calina, D. (2021). A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research, 46(9), 2205–2225. https://doi.org/10.1007/s11064-021-03376-0
