Green synthesis of multifunctional responsive hydrogel embedded with silver, based on xanthan gum, N-isopropylacrylamide, vinyl imidazole, and Luffa cylindrica for wound healing

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dc.authoridÖzay, Özgür/0000-0001-6589-9844
dc.contributor.authorAtli, Ilknur
dc.contributor.authorIlgin, Pinar
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T21:13:25Z
dc.date.available2025-01-27T21:13:25Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, a pH- and temperature-responsive smart hydrogel was developed by utilizing Xanthan Gum (XG), N-Isopropylacrylamide (NIPAM), Vinyl Imidazole (VI), and Luffa cylindrical (LC). Semi-interpenetrating polymer networks (semi-IPNs) were created using free radical polymerization with N,N '-methylenebisacrylamide (MBA) as the cross-linker and ammonium persulfate (APS) as the initiator. Silver nanoparticles (AgNPs) were synthesized within semi-IPN hydrogel network structures to impart antibacterial properties. Malva sylvestris (MS) aqueous leaf extract was used as a reducing and stabilizing agent for the green synthesis of the AgNPs. The semi-IPN hydrogels exhibited pH- and temperature-responsive swelling behavior, which also enabled the controlled release of the drug. After 11 h, the cumulative release reached approximately 73% at pH 7.2 and 87% at pH 8.3. Additionally, the sustained release mechanism of the Trimethoprim drug was described using the Korsmeyer-Peppas model and was governed by Fickian diffusion. The drug-loaded semi-IPN@Ag nanocomposite hydrogel has demonstrated effective antibacterial activity against various Gram-negative and Gram-positive bacteria, indicating its promising potential as a wound dressing material for reducing infection risk.
dc.identifier.doi10.1080/10601325.2024.2417176
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.scopus2-s2.0-85207521970
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/10601325.2024.2417176
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28413
dc.identifier.wosWOS:001339492000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSemi-IPN hydrogels
dc.subjectNIPAM
dc.subjectsilver
dc.subjectgreen synthesis
dc.subjectLuffa cylindrical
dc.titleGreen synthesis of multifunctional responsive hydrogel embedded with silver, based on xanthan gum, N-isopropylacrylamide, vinyl imidazole, and Luffa cylindrica for wound healing
dc.typeArticle

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