Deciphering the genotoxic and cytotoxic properties of teicoplanin: a combined laboratory and computational investigation

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dc.authoridBerber, Ahmet Ali / 0000-0002-2036-6929
dc.authoridAlıravcı, Işıl Deniz / 0000-0002-4740-1579
dc.authoridAkıncı Kenanoğlu, Nihan / 0000-0002-3917-6412
dc.contributor.authorBerber, Ahmet Ali
dc.contributor.authorAlıravcı, Işıl Deniz
dc.contributor.authorAkıncı Kenanoğlu, Nihan
dc.contributor.authorDemir, Şefika Nur
dc.date.accessioned2025-05-29T02:57:46Z
dc.date.available2025-05-29T02:57:46Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, the mutagenicity and carcinogenicity of the teicoplanin antibiotic were first investigated using the Vega Hub and Toxtree software through in silico prediction. The cytotoxic and genotoxic effects were evaluated using in vitro assays, including the mitotic index (MI), micronucleus (MN), nuclear division index (NDI), and Comet Assay (CA) in human lymphocytes. In the in vitro studies, both 24-hour and 48-hour exposures were conducted for MI, and teicoplanin significantly decreased MI compared to the control at all concentrations. In addition, a significant increase was detected in the MN frequency compared to the negative control at all concentrations. In the Comet assay, tail length significantly increased compared to the control at all concentrations except for 5.6 mu g/mL, while tail moment and comet tail intensity significantly increased at all concentrations compared to the control. In conclusion, within the concentration range used in this study, teicoplanin was found to have cytotoxic and genotoxic effects.
dc.description.sponsorshipScientific Research Projects coordination unit of Canakkale Onsekiz Mart university [thD-2022-3964]
dc.description.sponsorshipthis study was supported by the Scientific Research Projects coordination unit of Canakkale Onsekiz Mart university under project number thD-2022-3964.
dc.identifier.doi10.1080/01480545.2025.2502446
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid40337791
dc.identifier.scopus2-s2.0-105004431993
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/01480545.2025.2502446
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30173
dc.identifier.wosWOS:001484065700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectGenotoxicity
dc.subjectcytotoxicity
dc.subjectmicronucleus
dc.subjectmitotic index
dc.subjectcomet
dc.subjectteicoplanin
dc.subjectin silico
dc.titleDeciphering the genotoxic and cytotoxic properties of teicoplanin: a combined laboratory and computational investigation
dc.typeArticle

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