Evaluation of DNA damages in congenital hearing loss patients

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dc.authorscopusid57204928469en_US
dc.authorscopusid57195554629en_US
dc.authorscopusid22733342800en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorÇağlar, Özge
dc.contributor.authorÇobanoğlu, Hayal
dc.contributor.authorUslu, Atilla
dc.contributor.authorÇayır, Akın
dc.date.accessioned2025-02-10T07:41:10Z
dc.date.available2025-02-10T07:41:10Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractIn the current study, we aimed to compare the level of genetic damages measured as micronucleus (MN), nucleoplasmic bridge (NPB), and nuclear bud formation (NBUD) in congenital hearing loss patients (n = 17) and control group (n = 24). The cytokinesis-blocked micronucleus assay (CBMN) was applied to the blood samples to measure the frequency of the markers in both groups. The frequencies of MN of hearing loss patients were found to be consistently significantly higher than those obtained for the control group (p < 0.0001). Similarly, we found significantly higher frequency of NPB in patients was obtained for the patient group (p < 0.0001). Finally, the frequencies of NBUD in patients is significantly higher than the level measured in the control group (p < 0.0001). Furthermore, the age-adjusted MNL, BNMN, NPB, and NBUD frequencies in the patients were significantly higher than those obtained in the control group. We observed that the frequency of MN in patients was positively correlated with NBUD frequency which may indicate a common mechanism for these biomarkers in the patient group. We found, for the first time, that there were statistically significant higher levels of MN, NPB, and NBUD in sensorineural hearing loss patients. Since the markers we evaluated were linked with crucial diseases, our findings might suggest that sensorineural hearing loss patients are susceptible to several crucial diseases, especially cancer. Furthermore, the results demonstrated the significance of the MN, NPB, and NBUD level and thus provides a potential marker for the diagnosis of congenital hearing loss patients.en_US
dc.identifier.citationÇağlar, Ö., Çobanoğlu, H., Uslu, A., & Çayır, A. (2021). Evaluation of DNA damages in congenital hearing loss patients. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 822. https://doi.org/10.1016/j.mrfmmm.2021.111744en_US
dc.identifier.doi10.1016/j.mrfmmm.2021.111744en_US
dc.identifier.isbn0027-5107 / 1873-135X
dc.identifier.pmidPMID: 33934048en_US
dc.identifier.scopus2-s2.0-85104908808en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.mrfmmm.2021.111744
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29599
dc.identifier.volume822en_US
dc.identifier.wosWOS:000655327500003en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇağlar, Özge
dc.institutionauthorÇobanoğlu, Hayal
dc.institutionauthorÇayır, Akın
dc.institutionauthorid0000-0001-8737-2891
dc.institutionauthorid0000-0001-9640-3354
dc.institutionauthorid0000-0002-2014-6635
dc.language.isoengen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMutation Research - Fundamental and Molecular Mechanisms of Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA damageen_US
dc.subjectMicronucleusen_US
dc.subjectNuclear buden_US
dc.subjectNucleoplasmic bridgeen_US
dc.subjectSensorineural hearing lossen_US
dc.titleEvaluation of DNA damages in congenital hearing loss patientsen_US
dc.typearticleen_US

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