Evaluation of DNA damages in congenital hearing loss patients
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the current study, we aimed to compare the level of genetic damages measured as micronucleus (MN), nucleoplasmic bridge (NPB), and nuclear bud formation (NBUD) in congenital hearing loss patients (n = 17) and control group (n = 24). The cytokinesis-blocked micronucleus assay (CBMN) was applied to the blood samples to measure the frequency of the markers in both groups. The frequencies of MN of hearing loss patients were found to be consistently significantly higher than those obtained for the control group (p < 0.0001). Similarly, we found significantly higher frequency of NPB in patients was obtained for the patient group (p < 0.0001). Finally, the frequencies of NBUD in patients is significantly higher than the level measured in the control group (p < 0.0001). Furthermore, the age-adjusted MNL, BNMN, NPB, and NBUD frequencies in the patients were significantly higher than those obtained in the control group. We observed that the frequency of MN in patients was positively correlated with NBUD frequency which may indicate a common mechanism for these biomarkers in the patient group. We found, for the first time, that there were statistically significant higher levels of MN, NPB, and NBUD in sensorineural hearing loss patients. Since the markers we evaluated were linked with crucial diseases, our findings might suggest that sensorineural hearing loss patients are susceptible to several crucial diseases, especially cancer. Furthermore, the results demonstrated the significance of the MN, NPB, and NBUD level and thus provides a potential marker for the diagnosis of congenital hearing loss patients.
Açıklama
Anahtar Kelimeler
DNA damage, Micronucleus, Nuclear bud, Nucleoplasmic bridge, Sensorineural hearing loss
Kaynak
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
822
Sayı
Künye
Çağlar, Ö., Çobanoğlu, H., Uslu, A., & Çayır, A. (2021). Evaluation of DNA damages in congenital hearing loss patients. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 822. https://doi.org/10.1016/j.mrfmmm.2021.111744
