Modulation of the ubiquitin-proteasome system by curcumin: Therapeutic implications in cancer

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dc.contributor.authorTorghabe, Shima Yahoo
dc.contributor.authorAlavi, Parisa
dc.contributor.authorRostami, Sara
dc.contributor.authorDavies, Neal M.
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorKarav, Sercan
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2025-01-27T18:55:54Z
dc.date.available2025-01-27T18:55:54Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBy the ubiquitin-proteasomes, cellular proteins are structurally degraded and turnover. Many essential functions and regulations of cells are regulated and controlled by these proteins. Recent studies indicated that many cancer types have been associated with aberrations in the ubiquitination pathway, which involves three enzymatic steps. Dietary phytochemicals have been identified as having the potential to inhibit carcinogenesis recently. As part of this group of phytochemicals, curcumin can play a crucial role in suppressing carcinogenesis by changing many reactions affected by the ubiquitin-proteasome pathway. Due to its ability to change some biological processes such as NF-?B, inhibit some cyclins, and induce apoptosis, it can be used as a drug in cancer treatment. Copyright © 2024 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.prp.2024.155741
dc.identifier.issn1618-0631
dc.identifier.pmid39612810
dc.identifier.scopus2-s2.0-85212457480
dc.identifier.scopusqualityQ2
dc.identifier.startpage155741
dc.identifier.urihttps://doi.org/10.1016/j.prp.2024.155741
dc.identifier.urihttps://hdl.handle.net/20.500.12428/12746
dc.identifier.volume265
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofPathology, research and practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectCancer; Prteasome; Tumorgenesis; Turmeric; Ubiquitination; UPS pathway
dc.titleModulation of the ubiquitin-proteasome system by curcumin: Therapeutic implications in cancer
dc.typeReview Article

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