Modulation of the ubiquitin-proteasome system by curcumin: Therapeutic implications in cancer
[ X ]
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
By the ubiquitin-proteasomes, cellular proteins are structurally degraded and turnover. Many essential functions and regulations of cells are regulated and controlled by these proteins. Recent studies indicated that many cancer types have been associated with aberrations in the ubiquitination pathway, which involves three enzymatic steps. Dietary phytochemicals have been identified as having the potential to inhibit carcinogenesis recently. As part of this group of phytochemicals, curcumin can play a crucial role in suppressing carcinogenesis by changing many reactions affected by the ubiquitin-proteasome pathway. Due to its ability to change some biological processes such as NF-?B, inhibit some cyclins, and induce apoptosis, it can be used as a drug in cancer treatment. Copyright © 2024 Elsevier GmbH. All rights reserved.
Açıklama
Anahtar Kelimeler
Cancer; Prteasome; Tumorgenesis; Turmeric; Ubiquitination; UPS pathway
Kaynak
Pathology, research and practice
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
265
