Evaluation of the Antigenotoxic Effect of Quercetin Against Antiepileptic Drug Genotoxicity by Comet Analysis

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dc.authoridCanbolat, Fadime / 0000-0001-6759-7735
dc.authoridAkıncı Kenanoğlu, Nihan / 0000-0002-3917-6412
dc.authoridBerber, Ahmet Ali / 0000-0002-2036-6929
dc.contributor.authorCanbolat, Fadime
dc.contributor.authorAkıncı Kenanoğlu, Nihan
dc.contributor.authorYüksel, Tuğba Nurcan
dc.contributor.authorBerber, Ahmet Ali
dc.date.accessioned2025-01-27T19:20:26Z
dc.date.available2025-01-27T19:20:26Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractValproic acid (VPA) is among the most commonly used antiepileptic drugs in childhood and adult epilepsy. Although VPA is well tolerated, it can cause life-threatening side effects. VPA has toxic and genotoxic effects. Antioxidants can reverse drugs' toxic and genotoxic effects. Therefore, our study aimed to evaluate the antigenotoxic protective effect of quercetin (QUE) against VPA genotoxicity by in vitro comet assay analysis method. Comet assay analysis was performed in five different groups. Group I; negative control (Sterile H2O), Group II; positive control (H2O2), Group III; VPA was applied in four different dose ranges, Group IV; QUE was applied in four different dose ranges, Group V; For the simultaneous combined administration of VPA and QUE, three different doses of VPA + four different doses of QUE were administered. Low-dose administration of QUE was more effective in ameliorating the damage caused by low-dose VPA (62.5 ?g/ml) administration. It is seen that the genotoxic damage caused by the application of 125 ?g/ml VPA can be eliminated by QUE at all doses. It was determined that different doses of QUE exhibited a significant antigenotoxic effect against damage caused by 125 µg/mL VPA (P<0.05). In our study, the curative effect of QUE on DNA damage was determined by in vitro comet analysis. Our analysis results showed that QUE ameliorates VPA-induced genetic damage.
dc.identifier.doi10.16984/saufenbilder.1339199
dc.identifier.endpage1196
dc.identifier.issn1301-4048
dc.identifier.issn2147-835X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85187305572
dc.identifier.scopusqualityQ4
dc.identifier.startpage1185
dc.identifier.trdizinid1212392
dc.identifier.urihttps://doi.org/10.16984/saufenbilder.1339199
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1212392
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14869
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSakarya Üniversitesi
dc.relation.ispartofSakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectValproic acid
dc.subjectcomet assay
dc.subjectin vitro
dc.subjectquercetin
dc.titleEvaluation of the Antigenotoxic Effect of Quercetin Against Antiepileptic Drug Genotoxicity by Comet Analysis
dc.typeArticle

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