Cinnamaldehyde-poly (lactic acid)/gelatin nanofibers exhibiting antibacterial and antibiofilm activity

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dc.contributor.authorAkpinar, Zeynep
dc.contributor.authorUlusoy, Seyhan
dc.contributor.authorAkgun, Mert
dc.contributor.authorOral, Ayhan
dc.contributor.authorSuner, Salih Can
dc.date.accessioned2025-01-27T20:53:53Z
dc.date.available2025-01-27T20:53:53Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBacterial infections and biofilms are known to impede the wound-healing process. Naturally derived compounds from plants hold promise in inhibiting or preventing bacterial biofilms, with cinnamaldehyde (CA) being recognized for its antibacterial and antibiofilm properties. In this investigation, three-dimensional, antibacterial, and biodegradable nanofibers were synthesized via electrospinning, employing FDA-approved polylactic acid (PLA), gelatin (Gel), and the phytoactive molecule cinnamaldehyde (CA). The cinnamaldehyde content, morphology, and physical as well as biological characteristics of the electrospun PLA-Gel-CA nanofibers were scrutinized using HPLC, SEM, TGA, and FTIR analysis. The antibacterial activity of the PLA-Gel-CA nanofibers against Staphylococcus aureus and Pseudomonas aeruginosa, along with their antibiofilm activity against P. aeruginosa, were evaluated. The average diameters of PLA-Gel-CA nanofibers, specifically PLA-Gel-CA1, PLA-Gel-CA2, and PLA-Gel-CA3, were determined to be 294.9 +/- 46.8 nm, 254 +/- 58.3 nm, and 728.5 +/- 98.3 nm, respectively. PLA-Gel-CA3 nanofibers demonstrated notable antibacterial efficacy against S. aureus (31.0 +/- 1.20 mm) and P. aeruginosa (16.0 +/- 1.20 mm), along with a significant inhibition of P. aeruginosa biofilm formation by 72.2%. These findings indicate the potential of cinnamaldehyde-loaded nanofibers for wound application owing to their antibacterial and antibiofilm activity, as well as their rapid dissolution characteristics.
dc.description.sponsorshipScientific Research Project Funding Unit at Suleyman Demirel University [FYL-2018-6868]
dc.description.sponsorshipThis study was funded by the Scientific Research Project Funding Unit at Suleyman Demirel University (Project No: FYL-2018-6868).
dc.identifier.doi10.1080/00914037.2024.2395879
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.scopus2-s2.0-85202748850
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/00914037.2024.2395879
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25887
dc.identifier.wosWOS:001301236200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAntibacterial
dc.subjectantibiofilm
dc.subjectcinnamaldehyde
dc.subjectnanofibers
dc.subjectPLA
dc.titleCinnamaldehyde-poly (lactic acid)/gelatin nanofibers exhibiting antibacterial and antibiofilm activity
dc.typeArticle

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