Fabrication of Electrochemical Immunosensor for Detection of Interleukin 8 Biomarker via Layer-by-layer Self-assembly Process on Cost-effective Fluorine Tin Oxide Electrode
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A highly sensitive impedimetric immunosensor for the determination of interleukin 8 (IL 8) cancer biomarker was fabricated via simple fabrication process. A silane agent with isocyanate groups, 3-(triethoxysilyl)propyl isocyanate (IPTES), were utilized for binding of IL 8 antigen specific antibodies and self-assembled on the fluorine tin oxide (FTO) substrate with a standard silanization chemistry. Under optimum experimental conditions, the designed immunosensor had a wide linear detection range of 0.02-4 pg/mL, a low limit of detection of 11.9 fg/mL and a high sensitivity of 4.42 k omega pg(-1) mL cm(-2). The designed biosensor displayed high reproducibility and repeatability, good selectivity against interference biomarkers.
Açıklama
Anahtar Kelimeler
Electrochemical Analysis, Chemicals and Materials, Real Sample Analysis, Chemical Characterization, Interleukin, Fluorine tin oxide3, (triethoxysilyl)Propyl Isocyanate, Disposable Electrode
Kaynak
Electroanalysis
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
33
Sayı
6
Künye
Aydın, E. B., & Sezgintürk, M. K. (2021). Fabrication of Electrochemical Immunosensor for Detection of Interleukin 8 Biomarker via Layer‐by‐layer Self‐assembly Process on Cost‐effective Fluorine Tin Oxide Electrode. Electroanalysis, 33(6), 1596–1605. https://doi.org/10.1002/elan.202060603