Fabrication of Electrochemical Immunosensor for Detection of Interleukin 8 Biomarker via Layer-by-layer Self-assembly Process on Cost-effective Fluorine Tin Oxide Electrode

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Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Wiley

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

A highly sensitive impedimetric immunosensor for the determination of interleukin 8 (IL 8) cancer biomarker was fabricated via simple fabrication process. A silane agent with isocyanate groups, 3-(triethoxysilyl)propyl isocyanate (IPTES), were utilized for binding of IL 8 antigen specific antibodies and self-assembled on the fluorine tin oxide (FTO) substrate with a standard silanization chemistry. Under optimum experimental conditions, the designed immunosensor had a wide linear detection range of 0.02-4 pg/mL, a low limit of detection of 11.9 fg/mL and a high sensitivity of 4.42 k omega pg(-1) mL cm(-2). The designed biosensor displayed high reproducibility and repeatability, good selectivity against interference biomarkers.

Açıklama

Anahtar Kelimeler

Electrochemical Analysis, Chemicals and Materials, Real Sample Analysis, Chemical Characterization, Interleukin, Fluorine tin oxide3, (triethoxysilyl)Propyl Isocyanate, Disposable Electrode

Kaynak

Electroanalysis

WoS Q Değeri

Q3

Scopus Q Değeri

Cilt

33

Sayı

6

Künye

Aydın, E. B., & Sezgintürk, M. K. (2021). Fabrication of Electrochemical Immunosensor for Detection of Interleukin 8 Biomarker via Layer‐by‐layer Self‐assembly Process on Cost‐effective Fluorine Tin Oxide Electrode. Electroanalysis, 33(6), 1596–1605. https://doi.org/10.1002/elan.202060603 ‌