Drug release properties of amphoteric HES/p(AETAC-co-IA) hydrogels decorated with gold nanoparticles

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dc.authoridÖzay, Özgür / 0000-0001-6589-9844
dc.contributor.authorİlkiner, Merve
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:52:08Z
dc.date.available2025-01-27T20:52:08Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, amphoteric hydroxyethyl starch/p([2(acryloyloxy)ethyl]trimethylammonium chloride-co-itaconic acid (HES/p(AETAC-co-IA) hydrogels containing both cationic and anionic groups in their structure were synthesized by the redox polymerization method. The synthesized hydrogels were modified with gold nanoparticles, and nanocomposite hydrogels were obtained. The characterizations of the nanocomposite HES/p(AETAC-co-IA)@Au hydrogels prepared for biomedical applications were carried out by SEM, TEM, FT-IR, TGA, and XRD techniques and swelling tests in simulated biological environments. Hydrogels designed as drug carrier cargo materials were loaded with sodium diclofenac (NaDcF) and ibuprofen drugs, and their release properties were studied. The release mechanisms and release kinetics of the two drugs were studied. The release kinetics determined for the drug NaDcF is consistent with the Higuchi model, while the release kinetics determined for ibuprofen is consistent with the first-order model. In addition, the antibacterial and antifungal properties of the hydrogels were tested. It was found that the HES/p(AETAC-co-IA)@Au hydrogel was effective against gram-positive Staphylococcus aureus, gram-negative Pseudomonas aeruginosa, and the fungal species Candida albicans.
dc.description.sponsorshipCanakkale Onsekiz Mart University [FYL-2021-3854]
dc.description.sponsorshipThis research was funded by the Canakkale Onsekiz Mart University (FYL-2021-3854).
dc.identifier.doi10.1007/s13404-023-00334-2
dc.identifier.issn2364-821X
dc.identifier.issn2190-7579
dc.identifier.scopus2-s2.0-85171278244
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s13404-023-00334-2
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25670
dc.identifier.wosWOS:001066730400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofGold Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHydrogel
dc.subjectDrug delivery
dc.subjectNanocomposite
dc.subjectGold nanoparticle
dc.subjectAntibacterial material
dc.titleDrug release properties of amphoteric HES/p(AETAC-co-IA) hydrogels decorated with gold nanoparticles
dc.typeArticle

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