Electrochemical Immunosensor for Detection of CCR4 Cancer Biomarker in Human Serum: An Alternative Strategy for Modification of Disposable ITO Electrode

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dc.authorid0000-0003-3042-1087en_US
dc.authorscopusid6506764918en_US
dc.authorwosidAAY-1439-2021en_US
dc.contributor.authorAydın, Elif Burcu
dc.contributor.authorAydın, Muhammet
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.date.accessioned2024-12-10T08:01:11Z
dc.date.available2024-12-10T08:01:11Z
dc.date.issued2021en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractHerein, a new strategy for the fabrication of a sensitive immunosensor capable of determination of CC Chemokine receptor 4 (CCR4) in complex serum samples is developed through the polymer modification on the disposable indium tin oxide electrode. Anti-CCR4 antibodies, which are utilized as sensing biomolecules, are covalently attached on the succinimide groups of polypyrrole polymer (PPyr-CSsg). The constructed immunosensor illustrates promising performances for the quantification of CCR4 antigen, with a linear detection range of 0.024–12 pg mL−1 and a low detection limit of 7.3 fg mL−1, calculated at a signal-to-noise ratio of 3. In addition, the impedimetric immunosensor displays a very successful analytical performance in terms of sensitivity, selectivity, repeatability, reproducibility, and long-term stability as well as successful applicability for the accurate quantification of CCR4 in human serum samples. The constructed immunosensor is successfully used for quantification of CCR4 antigen in human serums. In addition, the immunosensor displays only 27.54% loss in its initial signal after nine weeks storage at 4 °C. Moreover, the fabricated immunosensor is economical, highly sensitive, and selective for CCR4 antigen detection, and suitable for potential application in clinical diagnosis.en_US
dc.identifier.citationAydın, E. B., Aydın, M., & Sezgintürk, M. K. (2021). Electrochemical Immunosensor for Detection of CCR4 Cancer Biomarker in Human Serum: An Alternative Strategy for Modification of Disposable ITO Electrode. Macromolecular bioscience, 21(2), e2000267. https://doi.org/10.1002/mabi.202000267en_US
dc.identifier.doi10.1002/mabi.202000267
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue2en_US
dc.identifier.pmid33108068
dc.identifier.scopus2-s2.0-85093976722
dc.identifier.urihttps://doi.org/10.1002/mabi.202000267
dc.identifier.urihttps://hdl.handle.net/20.500.12428/6723
dc.identifier.volume21en_US
dc.identifier.wosWOS:000583873700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSezgintürk, Mustafa Kemal
dc.language.isoen
dc.publisherWiley-VCH Verlagen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCC Chemokine receptor 4en_US
dc.subjectElectrochemical impedance spectroscopyen_US
dc.subjectImmunosensoren_US
dc.subjectPolypyrrole polymer containing succinimide groupsen_US
dc.titleElectrochemical Immunosensor for Detection of CCR4 Cancer Biomarker in Human Serum: An Alternative Strategy for Modification of Disposable ITO Electrode
dc.typeArticle

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