Enhanced antimicrobial and anticancer activities of zein protein-agarose@Au composite hydrogel for controlled release of silibinin in colon cancer therapy

Basit Öğe Kaydı
dc.authorid0000-0003-1152-120X
dc.contributor.authorAtli, Ilknur
dc.contributor.authorIlgin, Pinar
dc.contributor.authorKarabayir, Elif Sultan
dc.contributor.authorOzay, Hava
dc.contributor.authorOzay, Ozgur
dc.date.accessioned2026-02-03T12:02:43Z
dc.date.available2026-02-03T12:02:43Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, biodegradable hydrogel films based on natural proteins and polysaccharides were synthesized in order to improve controlled drug release, cytocompatibility and antibacterial properties. Biosynthesized gold nanoparticles were incorporated in situ cancer drug-loaded hydrogels to enhance their antibacterial, biocompatible, and cytotoxic characteristics. Then, in order to investigate the association of silibinin drug used in cancer treatment with AuNPs, drug release profile was evaluated under different environmental conditions and release kinetics were analyzed. In addition, antibacterial effects were determined by testing on Gram-negative and Gram-positive bacteria by Disk Diffusion method. As a result, cytocompatibility of silibinin drug and AuNPs in hydrogel networks and their effects on cancer cells were determined by MTT assay using human dermal fibroblasts (CCD1079KSk) and colon cancer (HT-29) cell lines. Thus, AuNPs created a synergistic effect in cancer treatment and strengthened the effect of Silibinin on tumor cells. In addition, it was determined that it exhibited a biocompatible structure by showing minimal toxicity to healthy human skin cells. This innovative drug delivery system has the potential to offer a biomaterial-based alternative in both cancer treatment and wound dressing material with its controlled release feature.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Commission/Coordination Unit [FBA-2024-4968]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University Scientific Research Projects Commission/Coordination Unit with project number FBA-2024-4968.
dc.identifier.doi10.1016/j.ijbiomac.2025.146286
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid40712877
dc.identifier.scopus2-s2.0-105011291667
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2025.146286
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34847
dc.identifier.volume321
dc.identifier.wosWOS:001549871500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectAgarose
dc.subjectZein
dc.subjectSilibinin
dc.subjectCancer
dc.subjectGold nanoparticle
dc.titleEnhanced antimicrobial and anticancer activities of zein protein-agarose@Au composite hydrogel for controlled release of silibinin in colon cancer therapy
dc.typeArticle

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