Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention

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dc.authorid0000-0003-0195-3383en_US
dc.authorid0000-0001-8989-8045en_US
dc.authorid-en_US
dc.authorid0000-0001-8859-0268en_US
dc.authorid-en_US
dc.authorid0000-0002-1740-4867en_US
dc.authorscopusid57203003221en_US
dc.authorscopusid57211689507en_US
dc.authorscopusid57815180000en_US
dc.authorscopusid57814005300en_US
dc.authorscopusid57210746729en_US
dc.authorscopusid22136607900en_US
dc.authorwosidAAR-5653-2020en_US
dc.authorwosidGSE-3886-2022en_US
dc.authorwosidGPT-0583-2022en_US
dc.authorwosidAEL-8468-2022en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorÖzleyen, Adem
dc.contributor.authorYılmaz, Yakup Berkay
dc.contributor.authorDönmez, Serhat
dc.contributor.authorAtalay, Hazal Nazlıcan
dc.contributor.authorAntika, Gizem
dc.contributor.authorBoyuneğmez Tümer, Tuğba
dc.date.accessioned2023-08-21T06:50:13Z
dc.date.available2023-08-21T06:50:13Z
dc.date.issued2023en_US
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Biyomoleküler Bilimler Ana Bilim Dalı
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Moleküler Biyoloji ve Genetik Ana Bilim Dalı
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed drug classes with wide therapeutic applications over the centuries. Starting from the use of salicylate-containing willow leaves to the recent rise and fall of highly selective cyclooxygenase-2 (COX-2) inhibitors and the latest dual-acting anti-inflammatory molecules, they have displayed a rapid and ongoing evolution. Despite the enormous advances in the last twenty years, investigators are still in search of the design and development of more potent and safer therapy against inflammatory conditions. This challenge has been increasingly attractive as the emergence of inflammation as a common seed and unifying mechanism for most chronic diseases. Indeed, this fact put the NSAIDs in the spotlight for repurposing against inflammation-related disorders. This review attempts to present a historical perspective on the evolution of NSAIDs, regarding their COX-dependent/independent mode of actions, structural and mechanism-based classifications, and adverse effects. Additionally, a systematic review of previous studies was carried out to show the current situation in drug repurposing, particularly in cancers associated with the GI tract such as gastric and colorectal carcinoma. In the case of non-GI-related cancers, preclinical studies elucidating the effects and modes of action were collected and summarized.en_US
dc.identifier.citationÖzleyen, A., Yılmaz, Y. B., Dönmez, S., Atalay, H. N., Antika, G., & Tümer, T. B. (2023). Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention. Journal of Cancer Research and Clinical Oncology, 149(5), 2095–2113. https://doi.org/10.1007/s00432-022-04187-8en_US
dc.identifier.doi10.1007/s00432-022-04187-8
dc.identifier.endpage2113en_US
dc.identifier.issn0171-5216
dc.identifier.issn1432-1335
dc.identifier.issue5en_US
dc.identifier.pmid35876951
dc.identifier.scopus2-s2.0-85134716768
dc.identifier.startpage2095en_US
dc.identifier.urihttps://doi.org/10.1007/s00432-022-04187-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4494
dc.identifier.volume149en_US
dc.identifier.wosWOS:000830857800004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzleyen, Adem
dc.institutionauthorYılmaz, Yakup Berkay
dc.institutionauthorDönmez, Serhat
dc.institutionauthorAtalay, Hazal Nazlıcan
dc.institutionauthorAntika, Gizem
dc.institutionauthorBoyuneğmez Tümer, Tuğba
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofJournal of Cancer Research and Clinical Oncologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/117Z398
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCanceren_US
dc.subjectDrug repurposingen_US
dc.subjectInflammationen_US
dc.subjectNSAIDsen_US
dc.subjectProstaglandinsen_US
dc.titleLooking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention
dc.typeReview Article

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