Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmiuminduced Oxidative Stress in Rats

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dc.authoridOZTURK, Samil/0000-0002-9435-8139
dc.authoridCAKINA, SUAT/0000-0002-3990-7641
dc.contributor.authorCakina, Suat
dc.contributor.authorIrkin, Latife Ceyda
dc.contributor.authorOzturk, Samil
dc.date.accessioned2025-01-27T21:03:33Z
dc.date.available2025-01-27T21:03:33Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Cadmium (Cd) is a well-known widespread environmental pollutant and is not rapidly excreted by the kidneys; instead, it accumulates and causes kidney damage. This study aimed to compare the effects of antioxidant curcumin and resveratrol on antioxidant defense in Cd-induced rat kidney tissue. Methods: In the study, 36 (200-250 gr) Wistar albino rats were divided into 6 (n=6) groups. Group 1: control; group 2: CdCl2; group 3: curcumin; group 4: CdCl2 + curcumin; group 5: resveratrol; group 6: CdCl2 + resveratrol. At the end of the experiment, malondialdehyde (MDA), total oxidant capacity (TOC), and total antioxidant capacity (TAC) activities were measured in kidney tissues. Results: In the CdCl2-treated group, oxidative stress index (OSI), TOC, and MDA levels increased compared with the control group, and TAC values decreased (p<0.05). In the case of resveratrol or curcumin administered with Cd, TAC levels increased, MDA levels, and OSI values decreased compared with the group administered only Cd (p<0.05). Conclusion: Both resveratrol and curcumin may have protective effects in the kidneys against CdCl2-induced oxidative damage.
dc.identifier.doi10.12996/gmj.2023.3705
dc.identifier.endpage148
dc.identifier.issn2147-2092
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85190576977
dc.identifier.scopusqualityQ4
dc.identifier.startpage145
dc.identifier.urihttps://doi.org/10.12996/gmj.2023.3705
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27336
dc.identifier.volume35
dc.identifier.wosWOS:001197084100007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCadmium
dc.subjectcurcumin
dc.subjectresveratrol
dc.subjectkidney damage
dc.titleProtective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmiuminduced Oxidative Stress in Rats
dc.title.alternativeSıçanlarda Kadmiyum Kaynaklı Oksidatif Strese Karşı Kurkumin ve Resveratrolün Böbrek Dokusu Üzerindeki Koruyucu Etkileri
dc.typeArticle

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