Optimizations related to the use of Lactobacillus helveticus, Kluyveromyces marxianus in monoculture, and co-culture for production of Spirulina-based fermented products

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dc.authoridÇınar, Zeynep Özlem / 0000-0002-3553-709X
dc.authoridAtalay, Hazal Nazlıcan / 0000-0001-8859-0268
dc.authoridBoyuneğmez Tümer, Tuğba / 0000-0002-1740-4867
dc.contributor.authorÖztürk, Naciye
dc.contributor.authorYay, Cansu
dc.contributor.authorÇınar, Zeynep Özlem
dc.contributor.authorAtalay, Hazal Nazlıcan
dc.contributor.authorGüneser, Onur
dc.contributor.authorİşleten Hoşoğlu, Müge
dc.contributor.authorBoyuneğmez Tümer, Tuğba
dc.date.accessioned2025-05-29T02:58:02Z
dc.date.available2025-05-29T02:58:02Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPresent study was carried out to optimize certain fermentation parameters when L. helveticus B-4526 and K. marxianus Y-329 were used in monoculture and co-culture in a medium supplemented with dried Spirulina platensis biomass (Spirulina medium). Maximum cell number increase for L. helveticus, K. marxianus in Spirulina medium was calculated as 2.40 and 3.80 log CFU mL-1, respectively. It was observed that proteins were rapidly hydrolyzed by L. helveticus. Consequently, the concentrations of some specific amino acids changed according to product type. The fermented Spirulina (FS) by K. marxianus resulted in higher trimethyl pyrazine content (2636.66 mu g kg- 1) than its unFS counterpart (2088.08 mu g kg- 1). All FS products resulted in increased inhibitory activity on acetylcholinesterase enzyme. FS product by co-culture of both organisms demonstrated a distinct suppressive effect on LPS-induced inflammatory NO secretion in RAW264.7 macrophage cell line. Besides, FS products did not show cytotoxicity in endothelial and macrophage cell lines, therefore presenting more biocompatible nature as compared to their unFS counterparts.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [218M389]; Canakkale Onsekiz Mart University [FYL-2022-4029]
dc.description.sponsorshipThis study funded by The Scientific and Technological Research Council of Turkey (Grant number 218M389) and partially supported by Canakkale Onsekiz Mart University (Scientific Research Projects, ID: FYL-2022-4029) . The authors also thank the Gebze Technical University, Gebze Enzyme Recognition Center (Kocaeli, Turkey) for providing laboratory infrastructure and support.
dc.identifier.doi10.1016/j.algal.2025.103948
dc.identifier.issn2211-9264
dc.identifier.scopus2-s2.0-85217238751
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.algal.2025.103948
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30248
dc.identifier.volume86
dc.identifier.wosWOS:001426688000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofAlgal Research-Biomass Biofuels and Bioproducts
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectSpirulina biomass
dc.subjectFermentation
dc.subjectOptimization
dc.subjectVolatile organic compounds
dc.subjectAmino acid composition
dc.subjectBioactive properties
dc.titleOptimizations related to the use of Lactobacillus helveticus, Kluyveromyces marxianus in monoculture, and co-culture for production of Spirulina-based fermented products
dc.typeArticle

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