Dual use of poly(3-sulfopropyl acrylate)/pectin hydrogels functionalized with silver and quantum dots for antibacterial wound care and sustained doxorubicin delivery

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dc.authorid0009-0003-1804-4036
dc.authorid0000-0001-6589-9844
dc.contributor.authorAtli, Ilknur
dc.contributor.authorOzay, Ozgur
dc.date.accessioned2026-02-03T12:02:24Z
dc.date.available2026-02-03T12:02:24Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, poly(3-sulfopropyl acrylate)/pectin hydrogels were synthesized by redox polymerization and their usability was demonstrated for two different applications. Silver nanoparticles used for the modification of the hydrogels were obtained by in-situ green synthesis in a hydrogel matrix using avocado pit extract and their antibacterial properties were investigated. In addition, hydrogels modified with quantum dots were used for the release of doxorubicin, a cancer drug. The synthesized hydrogels and composites were characterized by TEM, SEM, XRD, FT-IR, TGA and swelling tests. The p(SPA)/pectin@Ag hydrogel modified with silver nanoparticles showed strong antibacterial activity after cefazolin loading and achieved 91.6% cumulative drug release in approximately 300 h, conforming to Weibull kinetics. The p(SPA)/pectin@QD hydrogel composites modified with cadmium sulfide quantum dots exhibited high doxorubicin loading capacity and a pH-sensitive stable release profile, reaching 81.2% cumulative drug release in approximately 300 h. This behavior, which fits the Korsmeyer-Peppas model, demonstrates the suitability of the hydrogel composites for controlled chemotherapeutic drug delivery. In addition, cytotoxicity assay was performed on MCF-7 human breast cancer cells, and the cytotoxic effects of 10 and 5 mu g/mL doses were found to be 23.0 +/- 2.6% and 42.3 +/- 2.37%.
dc.description.sponsorshipanakkale Onsekiz Mart University Scientific Research Projects Commission [FBG-2025-5131]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University Scientific Research Projects Commission/Coordination Unit with Project number FBG-2025-5131.
dc.identifier.doi10.1080/10601325.2025.2588454
dc.identifier.endpage1347
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue12
dc.identifier.scopus2-s2.0-105022757435
dc.identifier.scopusqualityQ2
dc.identifier.startpage1334
dc.identifier.urihttps://doi.org/10.1080/10601325.2025.2588454
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34747
dc.identifier.volume62
dc.identifier.wosWOS:001618702900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectHydrogel
dc.subjectAg nanoparticle
dc.subjectquantum dot
dc.subjectcancer
dc.subjectdrug release
dc.titleDual use of poly(3-sulfopropyl acrylate)/pectin hydrogels functionalized with silver and quantum dots for antibacterial wound care and sustained doxorubicin delivery
dc.typeArticle

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