The role of AQP3 and AQP4 channels in cisplatin?induced cardiovascular edema and the protective efect of melatonin

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dc.authorid0000-0003-4646-4591en_US
dc.authorid0000-0002-3672-871Xen_US
dc.authorid0000-0003-4302-2157en_US
dc.authorid0000-0003-3590-2656en_US
dc.authorid0000-0003-1406-5473en_US
dc.authorscopusid12783716500en_US
dc.authorscopusid55897728300en_US
dc.authorscopusid57298805600en_US
dc.authorscopusid56200500500en_US
dc.authorscopusid7003873872en_US
dc.authorwosidFJN-4784-2022en_US
dc.authorwosidBBE-4885-2022en_US
dc.authorwosidECJ-4686-2022en_US
dc.authorwosidGES-9906-2022en_US
dc.authorwosidGHS-7148-2022en_US
dc.contributor.authorKoral, Lokman
dc.contributor.authorOvalı, Mehmet Akif
dc.contributor.authorTüfekçioğlu, Nezahat Kübra
dc.contributor.authorKarakılıç, Ersen
dc.contributor.authorAdalı, Yasemen
dc.contributor.authorUzun, Metehan
dc.date.accessioned2022-08-04T13:13:29Z
dc.date.available2022-08-04T13:13:29Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground The present study evaluates the development of edema, the change in the AQP3, AQP4, p53 and Bax gene expressions, and the protective efects of melatonin in rat hearts administered with cisplatin. Methods and Results A total of 28 Wistar albino rats were divided into four groups. The vehicle was administered intraperitoneally (i.p.) to the rats in the control group. The melatonin group (Mel) received melatonin at a dose of 10 mg/kg for 13 days. The cisplatin group (Cis) received cisplatin on days 1, 5, 9 and 13 at a dose of 4 mg/kg. The rats in the cisplatin + melatonin (Cis+Mel) group underwent the procedures both in the Mel and Cis groups. Blood and left ventricular samples were taken and analyzed on day 14 of the study. AQP3, p53 and Bax gene expressions were found to be signifcantly increased following cisplatin administration compared to the control, while melatonin administration signifcantly decreased the expression of these genes (p < 0.05). Melatonin administration also signifcantly decreased the level of AQP4 gene expression compared to the cis. On histological examination, congestion, hemorrhage, extracellular and intracellular edema, and degenerative changes were signifcantly more common in the Cis than in the control. Melatonin administration signifcantly decreased intracellular edema (p = 0.010) and degenerative changes (p = 0.010), and the improvement in extracellular edema was close to statistical signifcance (p = 0.051) in melatonin. Conclusions These results indicate that melatonin had an ameliorative efect on myocardial edema and AQP channels, and that it may be used as a protective molecule against myocardial edema secondary to cisplatin administration.en_US
dc.identifier.citationKoral, L., Ovali, M. A., Tufekcioglu, N. K., Karakilic, E., Adali, Y., & Uzun, M. (2021). The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin. Molecular Biology Reports, 48(11), 7457–7465. https://doi.org/10.1007/s11033-021-06763-6en_US
dc.identifier.doi10.1007/s11033-021-06763-6
dc.identifier.endpage7465en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue11en_US
dc.identifier.pmid34657253
dc.identifier.scopus2-s2.0-85117217626
dc.identifier.startpage7457en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06763-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3647
dc.identifier.volume48en_US
dc.identifier.wosWOS:000707690500004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKoral, Lokman
dc.institutionauthorOvalı, Mehmet Akif
dc.institutionauthorTüfekçioğlu, Nezahat Kübra
dc.institutionauthorKarakılıç, Ersen
dc.institutionauthorUzun, Metehan
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectAquaporin-3en_US
dc.subjectAquaporin-4en_US
dc.subjectMelatoninen_US
dc.subjectMyocardial Edemaen_US
dc.titleThe role of AQP3 and AQP4 channels in cisplatin?induced cardiovascular edema and the protective efect of melatonin
dc.typeArticle

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