The role of AQP3 and AQP4 channels in cisplatin?induced cardiovascular edema and the protective efect of melatonin
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background The present study evaluates the development of edema, the change in the AQP3, AQP4, p53 and Bax gene
expressions, and the protective efects of melatonin in rat hearts administered with cisplatin.
Methods and Results A total of 28 Wistar albino rats were divided into four groups. The vehicle was administered intraperitoneally (i.p.) to the rats in the control group. The melatonin group (Mel) received melatonin at a dose of 10 mg/kg for 13 days.
The cisplatin group (Cis) received cisplatin on days 1, 5, 9 and 13 at a dose of 4 mg/kg. The rats in the cisplatin + melatonin
(Cis+Mel) group underwent the procedures both in the Mel and Cis groups. Blood and left ventricular samples were taken
and analyzed on day 14 of the study. AQP3, p53 and Bax gene expressions were found to be signifcantly increased following
cisplatin administration compared to the control, while melatonin administration signifcantly decreased the expression of
these genes (p < 0.05). Melatonin administration also signifcantly decreased the level of AQP4 gene expression compared
to the cis. On histological examination, congestion, hemorrhage, extracellular and intracellular edema, and degenerative
changes were signifcantly more common in the Cis than in the control. Melatonin administration signifcantly decreased
intracellular edema (p = 0.010) and degenerative changes (p = 0.010), and the improvement in extracellular edema was close
to statistical signifcance (p = 0.051) in melatonin.
Conclusions These results indicate that melatonin had an ameliorative efect on myocardial edema and AQP channels, and
that it may be used as a protective molecule against myocardial edema secondary to cisplatin administration.
Açıklama
Anahtar Kelimeler
Cisplatin, Aquaporin-3, Aquaporin-4, Melatonin, Myocardial Edema
Kaynak
Molecular Biology Reports
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
48
Sayı
11
Künye
Koral, L., Ovali, M. A., Tufekcioglu, N. K., Karakilic, E., Adali, Y., & Uzun, M. (2021). The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin. Molecular Biology Reports, 48(11), 7457–7465. https://doi.org/10.1007/s11033-021-06763-6
