Temel Tıp Bilimleri Bölümü Koleksiyonu

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https://hdl.handle.net/20.500.12428/2277

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Effect of Hydrogen on Pentylenetetrazole-Induced Seizures in Ovariectomized Rats
(Springernature, 2025) Kaya, Miktat; Makav, Mustafa; Karadağ Sarı, Ebru; Yediel Aras, Şükran; Kuru, Mushap; Vural, Abdussamed; Eroğlu, Hüseyin Avni
The aim of the study was to investigate the therapeutic efficacy of hydrogen-rich water in pentylenetetrazol-induced epilepsy. A total of 30 female rats, 6 animals in each group, were used in the study. All groups except the control group were ovariectomized. Hydrogen-rich water Group (HRW) and Epilepsy + HRW Group (E + HRW) were administered intraperitoneally for 14 days. On the 14th day of the study, Epilepsy Group, HRW group and E + HRW group were administered a single dose of pentylenetetrazol intraperitoneally. Afterwards, all animals were recorded with a camera for 30 min and then epilepsy scoring was performed. All animals were then euthanized by cervical dissociation under anesthesia in accordance with ethical rules. Blood and tissue (brain and cerebellum) samples were collected from the animals. Biochemical measurements of MDA, GSH, native thiol, total thiol and disulfide homeostasis were performed. P53 and P27 genes were analyzed by PCR. Histopathological, routine hematoxylin and eosin and immunohistochemically BCL-2 and caspas-3 immunoreagents were examined. MDA data showed a statistically significant increase in the E group. Especially in the cerebellum tissue, a statistical decrease in the E + HRW group compared to the E group is remarkable. When GSH, Total thiol and Native thiol data were analyzed, a statistical decrease was observed in the E group. Especially in blood and cerebellum tissue, statistical increase in E + HRW group compared to E group is remarkable. P53 and P27 genes were statistically but numerically significant. There was also a significant difference in Bcl-2 and Caspas-3 immunoreactivity in the E + HRW group compared to the E group. In conclusion, hydrogen-rich water administration of the E + HRW group showed a therapeutic effect compared to E group. In the light of the results, we suggest that hydrogen-rich water may have a reactive effect in epilepsy.
Investigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive Acinetobacter baumannii Strain
(Mdpi, 2025) Yüksel, Cihan; Alıravcı, Işıl Deniz; Koşan, Murat; Esen, Sinem; Yenice Aktaş, Sevinç; Kaya Terzi, Neslihan; Berber, Ahmet Ali; Alkan, Sevil; Kaya, Selçuk
Background: This study aimed to evaluate the therapeutic efficacy of intravesical tigecycline administration in a rat model of cystitis induced by a tigecycline-sensitive, extensively drug-resistant (XDR) Acinetobacter baumannii strain. Methods: Thirty-six female Wistar albino rats were inoculated intravesically with XDR A. baumannii to induce cystitis. Twenty-four rats that developed infection were divided into four groups: untreated control, saline irrigation, low-dose tigecycline (6.25 mg/kg), and high-dose tigecycline (25 mg/kg). Microbiological clearance was assessed via urine cultures on days 3 and 5. Bladder tissues were analyzed histopathologically and for genotoxicity using the Comet assay. Results: On day 5, microbiological clearance was significantly higher in tigecycline-treated groups compared to controls (p = 0.028). Histopathology revealed significantly more inflammation in the high-dose tigecycline group (p = 0.029). Genotoxicity was observed in both tigecycline groups, independent of dose (p < 0.05). Conclusions: Intravesical tigecycline demonstrated microbiological efficacy against XDR A. baumannii-induced cystitis. However, its inflammatory and genotoxic potential necessitates further preclinical evaluation.
Machine Learning-Based Validation of LDHC and SLC35G2 Methylation as Epigenetic Biomarkers for Food Allergy
(Mdpi, 2025) Kılıçarslan, Sabire; Hız Çiçekliyurt, Meliha Merve; Kılıçarslan, Serhat; Hassan, Dina S. M.; Samee, Nagwan Abdel; Kurtoğlu, Ahmet
Background: Food allergies represent a growing global health concern, yet the current diagnostic methods often fail to distinguish between true allergies and food sensitivities, leading to misdiagnoses and inadequate treatment. Epigenetic alterations, such as DNA methylation (DNAm), may offer novel biomarkers for precise diagnosis. Methods: This study employed a computational machine learning framework integrated with DNAm data to identify potential biomarkers and enhance diagnostic accuracy. Differential methylation analysis was performed using the limma package to identify informative CpG features, which were then analyzed with advanced algorithms, including SVM (polynomial and RBF kernels), k-NN, Random Forest, and artificial neural networks (ANN). Deep learning via a stacked autoencoder (SAE) further enriched the analysis by uncovering epigenetic patterns and reducing feature dimensionality. To ensure robustness, the identified biomarkers were independently validated using the external dataset GSE114135. Results: The hybrid machine learning models revealed LDHC and SLC35G2 methylation as promising biomarkers for food allergy prediction. Notably, the methylation pattern of the LDHC gene showed significant potential in distinguishing individuals with food allergies from those with food sensitivity. Additionally, the integration of machine learning and deep learning provided a robust platform for analyzing complex epigenetic data. Importantly, validation on GSE114135 confirmed the reproducibility and reliability of these findings across independent cohorts. Conclusions: This study demonstrates the potential of combining machine learning with DNAm data to advance precision medicine in food allergy diagnosis. The results highlight LDHC and SLC35G2 as robust epigenetic biomarkers, validated across two independent datasets (GSE114134 and GSE114135). These findings underscore the importance of developing clinical tests that incorporate these biomarkers to reduce misdiagnosis and lay the groundwork for exploring epigenetic regulation in allergic diseases.
Virgin ureter vs. non-virgin ureter? A comparative analysis on complications and failure of retrograde intrarenal surgery: a multicentre case-control study from RIRSearch Group
(Springer, 2025) Teke, Kerem; Çınar, Naci Burak; Çınar, Önder; Akgül, Murat; Başataç, Cem; Şimşekoğlu, Muhammet Fatih; Çakır, Hakan; Sıddıkoğlu, Duygu; Sancak, Eyüp Burak
It is unclear whether ureteral virginity has an effect on retrograde intrarenal surgery (RIRS). We aimed to evaluate the impact of ureteral virginity on RIRS outcomes in a multicenter study. Data from the RIRSearch study group database were retrospectively reviewed. Patients with a history of endoluminal interventions or extrinsic ureteral surgery were categorized as having a non-virgin ureter, while those without such histories were classified as virgin ureters. Case-control matching was performed based on age, gender, uretral access sheath size, and stone characteristics. Demographic, clinical, surgical and complication data were compared after-matching. A total of 894 procedures were included, with 119 (13.3%) involving non-virgin ureters. Pre-matching, the non-virgin ureter group had higher mean age (50.6 +/- 13.2 vs. 46.6 +/- 13.6 years) and Charlson comorbidity index >= 2 (51.3% vs. 40.4%). In addition, number of stones, total-stone volume and rate of multiple stone localization were significantly higher in non-virgin ureter group. Operation time, hospital stay, surgical failure, need for auxiliary treatment, and perioperative complications were significantly higher in non-virgin ureter group (p < 0.05). After case-matching, perioperative complications (18.7% vs. 5.3%), hospital stay (1.54 +/- 1.30 vs. 1.18 +/- 0.98 days), and auxiliary treatment requirements (20% vs. 8.4%) remained significantly higher in non-virgin ureter group (p < 0.05). There was no significant difference in postoperative complication rates (17.3% vs. 19.8%) or surgical failure rates (36% vs. 26%). Non-virgin ureters were associated with higher perioperative complication rate, longer hospital stays and increased need for auxiliary treatments during RIRS. Patients with non-virgin ureters may be informed about these potential risks before surgery.
A Phosphodiesterase Type-5 (PDE-5) Inhibitor, Sildenafil, Ameliorates the NEC Induced Inflammation
(Springer, 2025) Ovalı, Mehmet Akif; Öztopuz, Özlem; Karaboğa, İhsan
The connection between intestine microbiota and lung disease is described as the gut-lung axis, these organ systems are somehow interrelated in both homeostasis and disease development. In newborns, the most important gastrointestinal complications are necrotizing enterocolitis (NEC), and the pulmonary complication both cause significant systemic morbidity. In this study, sildenafil administered at varying doses in neonatal rat model of experimental necrotizing enterocolitis and focused on both mRNA expression and histopathological alterations. 15-day-old Wistar Albino rat pups were randomly divided into six groups; Control, NEC, DMSO, Sil_1mg, Sil_5mg, Sil_10mg (n = 5). NEC induction was performed using hypoxia/asphyxia and cold stress. At the end of the experiment, lung tissues were harvested, molecular and histopathological alterations were analysed. Histopathological examination was performed with hematoxylin&eosin and masson trichrome staining in lung samples of neonatal rats and the mRNA expression levels of TNF-alpha, IL-6 and HSPa5 genes were analyzed. The mRNA expression levels of TNF-alpha, IL-6 and HSPa5 were increased in the NEC group compared to the control group and sildenafil treatment could significantly reduced the levels of the genes and inflammation (*p < 0.05 and **p <= 0.0001). Alveolar edema and hemorrhage findings were observed in the lung tissue of the NEC group. Interstitial edema and hemorrhage findings were reduced in the groups treated with sildenafil compared to the NEC group. The data we obtained indicate that sildenafil administering at different doses has therapeutic effect on NEC induced lung tissue inflammation both at the mRNA expression and tissue levels.
Investigation of Lycium barbarum Effects on Ovarium Damage Exposed to N-Methyl-N-Nitrourea
(Springer, 2025) Eroğlu, Hüseyin Avni; Büyük, Başak; Aydeğer, Cemre; Demir, Ufuk; Makav, Mustafa
N-Methyl-N-nitrourea (MNU), is one of the N-nitroso compounds that people are commonly exposed to in various exogenous ways such as diet, tobacco smoke, cosmetics, household goods, indoor air, occupational exposure, etc. It is known that the compound damages organs and tissues in the body, and one of the affected structures is the ovarium. Lycium barbarum, used in medication in ancient China, has become more popular in recent years. Previous studies have mentioned that polysaccharide ingredients are the most bioactive parts of Lycium barbarum. Therefore, this study aims to investigate the effects of Lycium barbarum polysaccharides (LBP) on ovarian tissue damage exposed to MNU. In accordance with this purpose, a total of 12 21-day-old female Wistar Albino rats were divided into two groups: sham and treatment. The animals were administrated with 50 mg/kg MNU (i.p.) on days 21, 28, 35, and 42. The treatment group was treated with 800 mg/kg LBP via intragastric for 30 days. At the end of the study, animals were sacrificed under general anaesthesia, and the ovarian tissues were harvested. Shrinkage of follicles, lytic oocytes, and disintegrated stroma parameters were evaluated histopathologically. The genetic assessment of the Bcl-2, Bax, Bcl-2/Bax ratio, Caspase 3, p53, and p27 expression levels were determined. The histopathological parameters between the groups were statistically significant (for all parameters p < 0.001). Moreover, the Bcl-2, Bcl-2/Bax ratio, and p53 relative fold changes were significantly increased in the treatment group (p < 0.001, p = 0.045, and p = 0.011, respectively). The results revealed that LBP has ameliorative effects on MNU-induced ovarian tissue damage. Further studies are required to clarify the main underlying mechanisms.
In silico molecular docking and in vitro analysis of atomoxetine
(Taylor & Francis Ltd, 2025) Bolat, Nurullah; Hız-Çelikliyurt, Merve Meliha; Akıncı, Erhan; Akkuş, Gülsüm; Günay, Melih; Korkmaz, Şükrü Alperen
Although atomoxetine, a selective norepinephrine reuptake inhibitor, is widely used in the treatment of attention-deficit/hyperactivity disorder (ADHD), there is limited data on its cytogenetic effects. This study aimed to investigate the cytotoxicity and genotoxicity of atomoxetine in vivo and silico. Chromosome aberration and micronucleus assays were used to analyze the genotoxic effect of atomoxetine in human peripheral blood lymphocytes under culture conditions. The mitotic index was assessed for cytotoxic potential. For the docking analysis, DNA receptor (1BNA) was prepared with ChimeraX, and the Atomoxetine molecule was optimized by Avogadro2.0 software. In silico molecular docking analysis was carried out utilizing SwissDock online platform. The results obtained were visualized using ChimeraX and Pymol software. Atomoxetine doses of 9.6 mu g/mL (equal to about 1.2 mg/kg as a maintenance dose), 14.4 mu g/mL (equal about to 1.8 mg/kg as the highest dose systematically tested), 48.0 mu g/mL (equal about to 6 mg/kg as five times the maintenance dose) and 96.0 mu g/mL (equal about to 12 mg/kg as ten times the maintenance dose) were analyzed. The findings clearly indicate that atomoxetine has no genotoxic effect at the therapeutic dose. However, we observed genotoxic effects at 48.0 and 96.0 mu g/mL doses. No strong binding affinity occurs in silico analyses. As one of the initial inquiries into the in silico and in vivo appraisal of atomoxetine's genotoxic impacts, the research has established that atomoxetine does not significantly affect the frequency of chromosomal damage or micronucleus formation. Genotoxic effects should be kept in mind at doses above clinical practice.
Humic acid attenuates cisplatin-induced nephrotoxicity in rats
(Taylor & Francis Ltd, 2025) Tekeş, Ender; İçkin Gülen, Meltem; Sılan, Coşkun; Güven Bağla, Aysel
Cisplatin-induced nephrotoxicity, a major limitation of this chemotherapeutic agent, involves oxidative stress, inflammation, and apoptosis. This study investigated the potential renoprotective effects of humic acid in a rat model of cisplatin-induced nephrotoxicity. Forty-two male Wistar rats were assigned to six groups: control, humic acid, cisplatin, cisplatin + humic acid 10 mg/kg, cisplatin + humic acid 20 mg/kg, and cisplatin + humic acid 40 mg/kg. On day 7, the rats were sacrificed, and cardiac blood and kidneys were collected for biochemical and histopathological examinations. Humic acid administration significantly attenuated the cisplatin-induced increases in renal TNF-alpha and NF-kappa B levels, indicating a reduction in inflammation. Humic acid also ameliorated histopathological damage, including Bowman's capsule dilatation, tubular cell degeneration, and hemorrhage. However, humic acid did not significantly alter oxidative stress parameters or caspase-3 levels. Humic acid demonstrates a protective effect against cisplatin-induced nephrotoxicity in rats, primarily by mitigating the inflammatory response. While HA's beneficial effects on oxidative stress and apoptosis were limited in this study, its ability to reduce inflammation highlights its potential as a therapeutic strategy to mitigate cisplatin-induced kidney injury.
Does the 5-Item Modified Frailty Index Predict Adverse Outcomes after Retrograde Intrarenal Surgery? A Case-Control Study by the RIRSearch Group
(Mary Ann Liebert, Inc, 2025) Başataç, Cem; Şimşekoğlu, Muhammed Fatih; Teke, Kerem; Tuna, Mustafa Bilal; Çınar, Önder; Akgül, Hacı Murat; Özman, Oktay; Sıddıkoğlu, Duygu; Sancak, Eyüp Burak
Objectives: We aim to assess whether severely frail patients have an increased risk of complications and worse surgical outcomes after retrograde intrarenal surgery. Methods: The data of 340 consecutive patients undergoing retrograde intrarenal surgery to treat upper tract urinary stones were analyzed retrospectively. The 5-item modified frailty index (mFI-5) was used to assess the frailty status. Using a cutoff value of score 2 in the mFI-5 score, patients were divided into two groups: patients with an mFI-5 score <2 were assigned to a non-frail (Group 1) group, and patients with an mFI-5 score ≥2 were assigned to a frail (Group 2) group. The patients’ demographics, stone characteristics, operative outcomes, and complication rates were compared between the groups. The primary objective was to examine whether the surgical outcomes were much better in non-frail patients. Results: After matching confounding factors, Group 1 comprised 255 patients, and Group 2 comprised 85 patients. The baseline characteristics were similar between the groups. There were no statistically significant differences in terms of the median operation time and length of hospital stay among groups. There were no significant differences between groups for intraoperative complication rates (7.6% and 9.4%, respectively; P = .47) and postoperative complication rates (13.8% and 11.8%, respectively; P = .71), and stone-free rates (70.9% versus 72.9%, respectively; P = .73). Conclusions: Retrograde intrarenal surgery is an efficient and feasible treatment option for upper urinary tract stones in severely frail patients.
Acute Measurement of Developmental Dysplasia of the Hip: Comparing Two Approaches for Measuring the Alpha Angle Using the Graf Technique
(Sage Publications Inc, 2025) Dindar, Fırat; Aylanç, Nilüfer; Aylanç, Hakan; Ertem, Şenay Bengin; Sıddıkoğlu, Duygu; Reşorlu, Mustafa
Objective: The Graf method, in ultrasonography screening of developmental hip dysplasia, is based on angle measurements. Using different reference points may cause varied results. The aim of this study was to investigate to what extent the alpha angle obtained, varied at different reference points.Materials and Methods: There were 178 hips evaluated by two trained observers. Both measured the alpha angle with different reference points and these were labeled as methods A and B, for all the hips evaluated. The statistical analysis was performed with SPSS Version 21.Results: The average of observer 1, based on measurements with method A, were 65.63 (SD +/- 5.95) and based on method B were 73.39 (SD +/- 6.29). The average of the measurements of observer 2, utilizing method A were 64.39 (SD +/- 4.85) and based on method B were 69.92 (SD +/- 6.08). It was observed that method B showed higher mean and variability compared to method A. The agreement between observers was moderate in method A and poor in method B. The intraobserver correlation coefficient (ICC) was 0.69 for method A and 0.47 for method B. The ICC was considered good (e.g., 95%) for both observers in terms of using methods A and B.Conclusion: The use of ultrasonography still maintains its place in the diagnosis of developmental hip dysplasia. The Graf method is based on precise measurements, and the most decisive parameter is the alpha angle. Reference points in method A would be more useful in patient management and may increase the diagnostic accuracy.
Is AI the future of evaluation in medical education?? AI vs. human evaluation in objective structured clinical examination
(Bmc, 2025) Tekin, Murat; Yurdal, Mustafa Onur; Toraman, Çetin; Korkmaz, Güneş; Uysal, İbrahim
BackgroundObjective Structured Clinical Examinations (OSCEs) are widely used in medical education to assess students' clinical and professional skills. Recent advancements in artificial intelligence (AI) offer opportunities to complement human evaluations. This study aims to explore the consistency between human and AI evaluators in assessing medical students' clinical skills during OSCE.MethodsThis cross-sectional study was conducted at a state university in Turkey, focusing on pre-clinical medical students (Years 1, 2, and 3). Four clinical skills-intramuscular injection, square knot tying, basic life support, and urinary catheterization-were evaluated during OSCE at the end of the 2023-2024 academic year. Video recordings of the students' performances were assessed by five evaluators: a real-time human assessor, two video-based expert human assessors, and two AI-based systems (ChatGPT-4o and Gemini Flash 1.5). The evaluations were based on standardized checklists validated by the university. Data were collected from 196 students, with sample sizes ranging from 43 to 58 for each skill. Consistency among evaluators was analyzed using statistical methods.ResultsAI models consistently assigned higher scores than human evaluators across all skills. For intramuscular injection, the mean total score given by AI was 28.23, while human evaluators averaged 25.25. For knot tying, AI scores averaged 16.07 versus 10.44 for humans. In basic life support, AI scores were 17.05 versus 16.48 for humans. For urinary catheterization, mean scores were similar (AI: 26.68; humans: 27.02), but showed considerable variance in individual criteria. Inter-rater consistency was higher for visually observable steps, while auditory tasks led to greater discrepancies between AI and human evaluators.ConclusionsAI shows promise as a supplemental tool for OSCE evaluation, especially for visually based clinical skills. However, its reliability varies depending on the perceptual demands of the skill being assessed. The higher and more uniform scores given by AI suggest potential for standardization, yet refinement is needed for accurate assessment of skills requiring verbal communication or auditory cues.
Recent insights into depression from transcriptomic analysis
(Termedia Publishing House Ltd, 2025) Günay, Melih; Çiçekliyurt, Meliha Merve
Purpose: Depression is a widespread mood disorder with a high rate of relapse and chronicity that can be affected by gender, and caused by traumatic or stressful events. Transcriptome analysis measures gene expression heterogeneity in cells, tissues, organs, and the whole body. The purpose of the study was to investigate both gender-specific and tissue-specific variations in gene expression regarding depression based on transcriptomic analysis using RNA-Seq data. Methods: The depression datasets GSE190518 and GSE214921 were downloaded from the Gene Expression Omnibus database provided by the NCBI. The GSE190518 datasets include peripheral blood samples (4 patients, 4 healthy controls), and the GSE214921 datasets contain human postmortem orbitofrontal cortex bulk tissue (20 patients, 19 healthy controls). All datasets were analyzed separately with the DESeq2 package in R. Later, GO and KEGG enrichment analyses of differentially expressed genes were performed using the clusterProfiler package in R. Results: Our results reveal that depression stimulates genes linked to the immune system, which is a common denominator in both brain tissue and blood samples. Overall, tissue-specific factors contribute to the association between depression and the immune system via distinct genes. Furthermore, gene ontology analyses revealed that HSPA6, HSPA7, HSPA1L, HSPA1A, and HSPA1B genes are co-represented in different pathways involved in molecular function, biological processes, and cellular components. Conclusions: Comparative transcriptomic evidence supports the immune hypothesis of depression in different tissue samples. Gender-specific depression may be triggered by protein misfolding.
Maculopapular Eruption in COVID-19 Patients: A Single-Center Comparative Study
(Galenos Publ House, 2025) Kaya, Özge; Alkan, Sevil; Mermutlu, Selda Işık; Cinpolat, Havva Yasemin; Kılıç, Sevilay Oğuz
Aim: Maculopapular eruption (MPE) due to the coronavirus disease 2019 (COVID-19) is increasingly reported. This study aimed to evaluate COVID-19 patients presenting with MPE and compare them with COVID-19 patients without MPE. Materials and Methods: COVID-19 patients with and without MPE followed up in a single tertiary center between March 2020 and December 2020 were assessed and compared in terms of demographic characteristics, clinical and laboratory findings. Results: A total of 114 COVID-19 patients (female: male ratio=0.4: 1, mean age: 51.44 +/- 16.62 years) confirmed by total polymerase chain reaction testing were evaluated. Patients with MPE during COVID-19 (n=44) and patients without MPE during COVID-19 (n= 70) were divided into two groups and compared. Among clinical findings, the incidence of fever, myalgia, anosmi and ageusia, rhinorrhea, and/or nasal congestion was significantly higher in COVID-19 patients with MPE. In terms of laboratory findings, creatinine, alkaline phosphatase (ALP), gamma-glutamyl transferase, lactate dehydrogenase, vitamin D, erythrocyte sedimentation rate, procalcitonin, ferritin, fibrinogen median levels were significantly higher in COVID-19 patients with MPE. In complete blood count, median hemoglobin, red blood cell, monocyte, eosinophil, and basophil counts were also significantly higher in the MPE group. In the multivariate logistic regression model, ALP was independently associated with MPE in COVID-19 patients (odds ratio: 1.099, 95% confidence interval: 1.056-1.144, p<0.00). Conclusion: The MPE in COVID-19 patients may be indicative of increased inflammation and organ damage. Early diagnosis and isolation of these patients and close follow-up are crucial in reducing the risk of organ damage and severe disease. In addition, ALP is an important laboratory parameter related to MPE in COVID-19 patients.
Bilişsel Esneklik Araştırmalarının Bibliyometrik Analizi ve Geleceğe Dair Görüler
(Pamukkale Üniversitesi Eğitim Fakültesi, 2025) Toraman, Çetin; Çalışkan, Çiğdem; Korkmaz, Güneş
Bu çalışma, Web of Science (WoS) verilerine dayalı olarak Bilişsel Esneklik (BE) konusundaki araştırmaların güncel durumunu ortaya koymayı ve gelişimini incelemeyi amaçlamaktadır. Çalışmada, 1975-2023 yılları arasında WoS'tan elde edilen meta veriler kullanılarak, BE üzerine yazılmış araştırma literatürünün haritalandırılması için bibliyometrik analiz yaklaşımı benimsenmiştir. Analiz, yayın yılına göre makale dağılımı ve ortalama atıf durumu, BE üzerine en fazla yayın yapan dergiler ve BE ile ilgili atıf sayısı, en çok atıf alan BE makaleleri ve yazarları, BE hakkındaki makalelerin en çok atıf aldığı ülkeler, BE üzerine en fazla makale üreten yazarlar, yayınları, yazarların ülkeleri ve makalelerde BE ile ilişkili kelimelerin eğilimi gibi faktörleri içermektedir. Sonuçlar, yıllara göre makale yayınlama eğilimi son yıllarda artmasına rağmen, BE makalelerine atıfların en yüksek artışının 1990 ve 1994 yıllarında yaşandığını ortaya koymaktadır. En fazla yayın yapan dergiler ise Behavioural Brain Research, Psychiatry Research, Frontiers in Behavioral Neuroscience, Journal of Experimental Child Psychology, Journal of Neuroscience dergileridir. Bir diğer bulgu ise, BE makalelerinin en çok atıf aldığı ve en yüksek üretim oranlarına sahip ülkenin ABD olduğudur. Ayrıca, BE makalelerinde en sık kullanılan kelimelerin esneklik, prefrontal korteks, beyin, çalışma belleği, görev, bilişsel, bellek, karar verme, korteks, aktivasyon, yanıt-engelleme, yürütücü işlev, interferans, bilişsel kontrol ve şizofreni olduğu tespit edilmiştir. Bu çalışma, BE literatürü hakkında kapsamlı bir değerlendirme sunmakta ve gelecekteki araştırmalar için alanın gelişimi hakkında ilginç bilgiler sağlamaktadır.
The effects of systemic ozone application and hyperbaric oxygen therapy on avascular necrosis of the femoral head: An experimental study in the vascular deprivation of the rat femoral head model
(Turkish Joint Diseases Foundation, 2025) Yılmaz, Onur; Erken, Hüseyin Yener; İçkin Gülen, Meltem; Güven Bağla, Aysel; Adalı, Yasemen; Kuru, Tolgahan
Objectives: This study aims to assess the effects of systemic medical ozone (O3) application and to compare its effects with hyperbaric oxygen (HBO) therapy for preventing avascular necrosis of the femoral head in a rat model. Materials and methods: A total of 50 male Wistar albino rats were divided into six groups including five rats in each control and sham-operated control group and 10 rats in the remaining four groups: (i) control group, (ii) sham-operated control group, (iii) avascular necrosis group, (iv) intraperitoneal ozone given avascular necrosis group, (v) HBO therapy given avascular necrosis group, and (vi) intraperitoneal ozone and HBO given avascular necrosis group. We surgically induced osteonecrosis by cutting the ligamentum teres and placing a tight ligature around the femoral neck. At Week 11, we harvested femoral heads bilaterally from each animal and performed a macroscopic, histological evaluation and histomorphometric, immunohistochemical analysis. Results: The intertrabecular mesenchymal cell ratio was substantially higher in the O3 group than that of all other groups in the histological evaluation (p<0.05). Group O3 had also significantly more CD31-positive stained new vasculature than other groups, with the exception of the HBO therapy group, according to the immunohistochemical analysis (p<0.05). Conclusion: The results of this experimental study suggest that the application of medical ozone alone may have a positive effect on new vessel formation and the repair process and may be more beneficial than HBO therapy and HBO+O3 therapy in the vascular deprivation of the rat femoral head model. © 2025 All right reserved by the Turkish Joint Diseases Foundation
Syphilis coinfection in individuals living with HIV: tertiary university hospital data
(Pamukkale University, 2025) Alıravcı, Işıl Deniz; Yenice Aktaş, Sevinç; Kaya, Selçuk
Purpose: This study aimed to examine the coinfection of syphilis in HIV-positive individuals and the epidemiological and clinical characteristics of these patients. Material and methods: Our study was conducted in Çanakkale Onsekiz Mart University, between 13.02.2018 and 13.02.2024, in 26 patients with clinically and laboratory-confirmed syphilis co-infection among 142 HIV/AIDS patients who were followed up and confirmed in the infectious diseases and clinical microbiology outpatient clinic. Results: A total of 142 HIV positive and 26 (18.3%) syphilis coinfected patients between the ages of 17-77 were included in the study. The mean ages of the infected and syphilis coinfected patients were 39.1 and 41.07, respectively. Six (23%) of the coinfected patients were married, the remaining 14 (53.8%) were single or divorced, five had multiple partners; 20 (77%) were heterosexual, four (15%) were men who have sex with men (MSM), and two (8%) were bisexual. Simultaneous HIV/syphilis positivity was detected in 14 (54%) of the coinfected patients at the time of diagnosis, while 7 (27%) were detected during the HIV treatment follow-up period, and 5 (19%) were detected before HIV diagnosis. Of the patients with coinfection, five (19.2%) had primary syphilis, 10 (38.5%) had latent syphilis, and 11 (42.3%) had secondary syphilis at the time of diagnosis. Twenty-two (85%) of the patients had been diagnosed and treated for syphilis only once, while the remaining (15%) had received two or more treatments. Conclusions: The prevalence of syphilis coinfection and reinfection in patients was 18.3% and 15%, respectively. In cases of coinfection, male gender, alcohol and drug consumption, being MSM, irregular lifestyles, and sexual habits were found to be effective. It is important to conduct screening for syphilis and other sexually transmitted diseases (STDs) in HIV-infected patients. Providing psychiatric support to these patients in organizing their life plans is also very important for preventing HIV transmission and syphilis coinfection. © 2025, Pamukkale University. All rights reserved.
The relationship between public health system resilience and psychological resilience: multilevel regression study
(Turkish Society of Public Health Specialists, 2025) Çan, Gamze; Kartal, Hakan; Toraman, Çetin; Bakar, Coşkun
Objective: This study aims to explore the effect of Public Health System Resilience (PHSR) on the psychological resilience of individuals. To demonstrate this interaction, the study investigated psychological resilience levels of individuals negatively affected by the recently experienced COVID-19 pandemic as a disaster period in the province of Çanakkale. Method: This study was conducted in two stages in April and September 2022. In the first stage, the PHSR Scorecard prepared by the United Nations Office for Disaster Risk Reduction was used to obtain the scores from the Merkez province of Çanakkale and the Bayramiç and Ayvacık districts. In the second stage, a questionnaire for demographic data and the Psychological Resistance Scale was administered to 510 people, including those over 65 years, small business owners, and students (high-school grades 2 and 3). The results were analyzed at two levels and with three different models using the Multilevel Regression analysis. Results: Based on the multilevel regression model formulated for the factors affecting Psychological Resilience, it was found that PHSR was an explanatory or predictor variable for psychological resilience, and a high public health system resilience was associated with a high psychological resilience (Model 1 ß:0,29, p<0,05), (Model 2 ß:0,26, p<0,01) (Model 3 ß:1,05, p<0,01). It was also found that in PHSR interactions, small business owner groups (β =-0,77, t=-2,35, p<0,05) and student groups (β =-1,56, t=4,72, p<0,01) were affected more negatively than the group aged over 65 years. Conclusion: Our study has demonstrated that PHSR effectively enhances individuals’ psychological resilience. © 2025 by the Association of Public Health Specialist.
Relationship of Polymorphisms and Haplotype in Klotho Gene with Hypertension Risk
(Pleiades Publishing, 2025) Çiçekliyurt, M.M.; Çolak, Y.; Balun, A.; Akgümüş, A.
Abstract: Klotho gene is linked to promoting healthy aging and longevity. With age, serum Klotho levels decrease, resulting in age-related disorders. Polymorphisms contribute to a range of risk factors associated with disease onset, disease response, and therapeutic adverse effects. Klotho gene polymorphisms are linked to cardiovascular illness, although previous studies did not evaluate their relationship with hypertension. In this context, polymorphisms in the KL gene that disrupt gene expression or cause regulatory proteins to bind to the promoter region may trigger hypertension. So, the aim of our study investigated how two non-synonymous SNPs (rs9536314 and rs9527025) at the Klotho gene are connected to high blood pressure. The study was a case-control consisting of 226 hypertensive and 126 healthy individuals. All individuals were genotyped by real-time PCR. KL rs9536314 and rs9527025 polymorphisms were evaluated for hypertension risk using allele/genotype counting, OR-value, logistic regression, and haplotype analysis. As a results, hypertensive patients with recessive genotypes had twice the risk as the general population. KL rs9527025 was not a significant risk factor for dominant, recessive, and additive-modelled hypertension. In contrast, individuals with KL rs9536314 had a higher risk of hypertension in the recessive model. In conclusion: KL-rs9536314T → G would greatly increase the risk of hypertension in the recessive model. © Pleiades Publishing, Inc. 2025.
Modified Dermal-Fat Flap Suspension Technique for Internal Nasal Valve Dysfunction: A Comparative Study With Conventional Cartilage Grafting
(Lippincott Williams and Wilkins, 2025) Akyürek, Mustafa; Çakır, Bahadır; Hafız, Güneş; Tavas, Ozan
Iatrogenic internal nasal valve (INV) dysfunction is a significant complication after nasal surgery, often necessitating revision surgeries involving cartilage grafting, which carries high risks of complications such as mucosal synechiae, septal perforations, and chronic inflammation. This study evaluates the efficacy of a modified dermal-fat flap suspension technique as an alternative to conventional cartilage grafting for INV reconstruction. A retrospective review was conducted of 30 patients treated between March 2019 and March 2023, including 8 patients who underwent the modified dermal suspension technique and 22 who received spreader grafts. Preoperative and postoperative nasal obstruction symptom evaluation scores were statistically analyzed using the Mann-Whitney U test. While both groups demonstrated significant postoperative improvements, no statistically significant differences were found between the groups. The modified technique, performed under local anesthesia, was associated with fewer complications and avoided extensive cartilage grafting or mucosal dissection, making it particularly suitable for patients with advanced age, high ASA scores, or complex surgical histories. Common complications included transient orbital edema and rare cases of skin discoloration, which resolved over time. Despite a small sample size and reliance on subjective nasal obstruction symptom evaluation scores, this study highlights the potential of the modified dermal-fat flap suspension technique as a less invasive, effective alternative for managing INV dysfunction, especially in high-risk patients. Further studies with larger cohorts and objective measures are needed to validate these findings. Copyright © 2025 by Mutaz B. Habal, MD.
Corrigendum to “Spatial distribution and isotopic signatures of N and C in mosses across Europe” [Sci. Total Environ. 958 (2025) 178043](S0048969724082007)(10.1016/j.scitotenv.2024.178043)
(Elsevier B.V., 2025) Izquieta-Rojano, Sheila; Morera-Gómez, Yasser; Elustondo, David; Lasheras, Esther; Santamaría, Carolina; Torrens-Baile, Julen; Alber, Renate; Coşkun, Mahmut; Coşkun, Münevver
The authors regret that the printed version of the above article contained two errors in the author list. The correct and final version of the author list and their corresponding affiliations follows. The added authors are Winfried Schröder and Harald G. Zechmeister. These individuals provided both samples and data from previously analyzed samples, and contributed to the initial manuscript draft. The authors would like to sincerely apologize for any inconvenience caused and greatly appreciate the understanding of the two authors mistakenly included and the two authors initially omitted. Sheila Izquieta-Rojanoa, Yasser Morera-Gómeza, David Elustondoa, Esther Lasherasa, Carolina Santamaríaa, Julen Torrens-Bailea, Renate Alberb, Lambe Barandovskic, Mahmut Coşkund, Munevver Coskune, Helena Danielssonf, Ludwig De Temmermang, Harry Harmensh, Zvonka Jerani, Sébastien Leblondj, Javier Martínez-Abaigark, Encarnación Núñez-Oliverak, Winfried Schröderl, Gunilla Pihl Karlssonf, Juha Piispanenm, Harald G. Zechmeistern, Zdravko Spirico, Trajče Stafilovc, Lotti Thönip, Jesús Miguel Santamaríaa aUniversidad de Navarra, Instituto de Biodiversidad y Medioambiente BIOMA, Irunlarrea 1, 31008 Pamplona, Spain bAgency for Environment and Climate Protection, Biological Laboratory, Unterbergstr. 2, 39055 Leifers, Italy cInstitute of Physics, Faculty of Natural Sciences and Mathematics, Ss Cyril and Methodius University in Skopje, POB 162, 1000 Skopje, Macedonia dCanakkale Onsekiz Mart University, Faculty of Medicine, Turkey eCanakkale Onsekiz Mart University, Vocational Health School, Turkey fIVL - Swedish Environmental Research Institute, Sweden gVeterinary and Agrochemical Research Centre CODA-CERVA, Tervuren, Belgium hUK Centre for Ecology & Hydrology, Environment Centre Wales, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK iJožef Stefan Institute, Ljubljana, Slovenia jPatriNat (OFB, MNHN), 12 Rue Buffon, CP39, 75005 Paris, France kUniversidad de La Rioja, Facultad de Ciencia y Tecnología, Madre de Dios 53, 26006 Logroño, Spain lChair of Landscape Ecology, University of Vechta, P.O.B. 1553, 49364 Vechta, Germany mNatural Resources Institute Finland, Paavo Havaksen tie 3, FI-90570 Oulu, Finland nUniversity of Vienna, Department of Biodiversity and Conservation Biology, Rennweg 14, 1030 Vienna, Austria oGreen Infrastructure Ltd., Borongajska cesta 81c., HR-10000 Zagreb, Croatia pFUB - Research Group for Environmental Monitoring, Alte Jonastrasse 83, 8640 Rapperswil, Switzerland © 2025 The Author(s)

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