IN VITRO EVALUATION OF THE ANTIOXIDANT, ANTIBACTERIAL, ANTIBIOFILM, AND CYTOTOXIC ACTIVITY OF MENTHA PIPERITA ESSENTIAL OIL

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dc.authorid0000-0001-7363-5056en_US
dc.authorscopusid55973446700en_US
dc.authorwosid-en_US
dc.contributor.authorAltun, Mehzat
dc.date.accessioned2024-01-24T08:01:14Z
dc.date.available2024-01-24T08:01:14Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractNowadays, antibacterial resistance to synthetic antibiotics has become a big issue worldwide. Mentha piperita essential oil (EO) and its bioactive components with antibacterial, antibiofilm, and antioxidant properties are recommended for the treatment of microbial infections in traditional medicine. This study aimed to detect phytochemical components, antioxidant and cytotoxic activity; to evaluate antibacterial and antibiofilm effects of M. piperita EO on strains. Gas chromatography/mass spectrometry (GC-MS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to determine chemical composition, antioxidant and cytotoxic potentials of EO, respectively. Antibacterial activity was carried out through disc diffusion and minimum inhibitory concentration (MIC) assays. The biofilm biomass of bacteria was determined by the crystal violet (CV) staining method. Menthone (27.28%), L-menthol (23.71%), and limonene (7.48%) were the main components. M. piperita EO was found to have strong antibacterial activity with the MIC-MBC values in the range of 0.125-16.00% (v/v) and moderate antioxidant activity. The peppermint EO showed an antibiofilm effect on all strains and a cytotoxic effect on NIH 3T3 cells. M. piperita EO may be used alone or in combination with antibiotics or carrier oils as a therapeutic agent against bacterial infections. Further in vivo experiments should be carried out to detect a safe dosage of EO.en_US
dc.identifier.citationAltun, M. (2023). IN VITRO EVALUATION OF THE ANTIOXIDANT, ANTIBACTERIAL, ANTIBIOFILM, AND CYTOTOXIC ACTIVITY OF MENTHA PIPERITA ESSENTIAL OIL. Journal of Microbiology, Biotechnology and Food Sciences, 12(5), e6206–e6206. https://doi.org/10.55251/jmbfs.6206en_US
dc.identifier.doi10.55251/jmbfs.6206
dc.identifier.endpage5en_US
dc.identifier.issn1338-5178
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85163085033
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.55251/jmbfs.6206
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5371
dc.identifier.volume12en_US
dc.identifier.wosWOS:000968697800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAltun, Mehzat
dc.language.isoen
dc.publisherSlovak University of Agricultureen_US
dc.relation.ispartofJournal of Microbiology, Biotechnology and Food Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAntibacterialen_US
dc.subjectAntibiofilmen_US
dc.subjectAntioxidanten_US
dc.subjectCytotoxicityen_US
dc.subjectMentha piperitaen_US
dc.titleIN VITRO EVALUATION OF THE ANTIOXIDANT, ANTIBACTERIAL, ANTIBIOFILM, AND CYTOTOXIC ACTIVITY OF MENTHA PIPERITA ESSENTIAL OIL
dc.typeArticle

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