Different chromatographic techniques and recent advancements for biomedical and pharmaceutical applications

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dc.contributor.authorCoskun, Ozlem
dc.contributor.authorAkbarzadeh, Sama
dc.contributor.authorGuncer, Basak
dc.date.accessioned2026-02-03T12:00:23Z
dc.date.available2026-02-03T12:00:23Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractChromatography remains a cornerstone analytical technique in pharmaceutical and biomedical sciences, with recent innovations significantly expanding its capabilities. Advances such as fast chromatography, two-dimensional liquid chromatography (2D-LC), supercritical fluid chromatography (SFC), and hyphenated techniques, including liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), have broadened the scope of its applications. These developments enhance resolution, sensitivity, and efficiency, enabling more robust analysis of complex biological and pharmaceutical samples. These methods address complex analytical challenges, improving precision, speed, and efficiency in separating and analyzing biomolecules. Emerging technologies, including miniaturized liquid chromatography, shear flow chromatography, column arrays, and microfluidic chip-based systems, present exciting opportunities for the future. These developments enhance the capability of chromatography to analyze trace compounds, optimize drug formulations, and ensure the quality control of pharmaceuticals. Chromatography is also increasingly integrated with cutting-edge techniques like metabolomics and proteomics, furthering its impact on biomarker discovery and personalized medicine. This paper reviews recent advancements in chromatographic methods and their practical applications in the pharmaceutical and biomedical fields. It highlights the critical role of chromatography in drug discovery, purification of therapeutic compounds, and metabolite profiling.
dc.identifier.doi10.14744/nci.2025.42966
dc.identifier.endpage752
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue6
dc.identifier.pmid41574145
dc.identifier.scopus2-s2.0-105027677119
dc.identifier.scopusqualityQ3
dc.identifier.startpage739
dc.identifier.urihttps://doi.org/10.14744/nci.2025.42966
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34596
dc.identifier.volume12
dc.identifier.wosWOS:001654566400002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectBiomedical analysis
dc.subjectbiomarker discovery
dc.subjectchromatography
dc.subjectpharmaceutical applications
dc.subjectprotein
dc.titleDifferent chromatographic techniques and recent advancements for biomedical and pharmaceutical applications
dc.typeArticle

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