Immunosuppressive influence of parasitoid wasp Pimpla turionellae calyx fluid on host Galleria mellonella cell-mediated immune response and hemocyte viability

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dc.authorid0000-0002-0984-2824en_US
dc.authorscopusid57217302216en_US
dc.authorwosidABB-9522-2020en_US
dc.contributor.authorKaya, Serhat
dc.contributor.authorUçkan, Fevzi
dc.contributor.authorEr, Aylin
dc.date.accessioned2023-05-16T06:29:10Z
dc.date.available2023-05-16T06:29:10Z
dc.date.issued2022en_US
dc.departmentFakülteler, Fen Fakültesi, Biyoloji Bölümü
dc.description.abstractEndoparasitoid species devoid of symbiotic viruses inject secretions derived from their reproductive glands into their hosts during parasitism in order to avoid various immune responses of their hosts. Pimpla turionellae L. (Hymenoptera: Ichneumonidae) is an endoparasitoid that lacks polydnaviruses, and its venom has previously been shown to paralyze the host Galleria mellonella (Lepidoptera: Pyralidae) and suppress its immune reactions to ensure the egg survival. The present study demonstrates that another female-injected factor calyx fluid extracted from the P. turionellae ovary is also responsible for the suppression of G. mellonella immunity. The total hemocyte counts of G. mellonella decrease after treatment with calyx fluid in a concentration-dependent manner. Significant reductions in cell viability are also observed at all calyx fluid doses both in vivo and in vitro. The analyses of the beads injected into the insects as encapsulation targets revealed that the number of encapsulated beads reduced significantly compared to controls post-calyx fluid injection. The injection of the highest calyx fluid dose (1 female equivalent calyx) is sufficient to completely inhibit the strong encapsulation and melanization reactions of the last instar larvae 24 h post-injection. These results demonstrate that P. turionellae calyx fluid is required to regulate host immunity for successful parasitization.en_US
dc.identifier.citationKaya, S., Uçkan, F., & Er, A. (2022). Immunosuppressive influence of parasitoid wasp pimpla turionellae calyx fluid on host galleria mellonella cell-mediated immune response and hemocyte viability. Bulletin of Entomological Research, 112(3), 361-369. doi:10.1017/S0007485321000924en_US
dc.identifier.doi10.1017/S0007485321000924
dc.identifier.endpage369en_US
dc.identifier.issn0007-4853
dc.identifier.issn1475-2670
dc.identifier.issue3en_US
dc.identifier.pmid34622756
dc.identifier.scopus2-s2.0-85117320088
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1017/S0007485321000924
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4160
dc.identifier.volume112en_US
dc.identifier.wosWOS:000744315500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaya, Serhat
dc.language.isoen
dc.publisherCambridge University Pressen_US
dc.relation.ispartofBulletin of Entomological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCalyxen_US
dc.subjectEncapsulationen_US
dc.subjectGalleria mellonellaen_US
dc.subjectHemocyteen_US
dc.subjectPimpla turionellaeen_US
dc.titleImmunosuppressive influence of parasitoid wasp Pimpla turionellae calyx fluid on host Galleria mellonella cell-mediated immune response and hemocyte viability
dc.typeArticle

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