Protective effects of swimming exercise on experimental rheumatoid arthritis in rats through modulation of leptin receptor expression and inflammation

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dc.authorid0000-0002-7948-5383
dc.authorid0000-0002-0510-9852
dc.authorid0000-0003-3139-3540
dc.authorid0000-0002-0020-1633
dc.authorid0000-0002-0606-6364
dc.contributor.authorDurasilli, Tugce Yavas
dc.contributor.authorZateri, Coskun
dc.contributor.authorYuksel, Pinar
dc.contributor.authorSaker, Dilek
dc.contributor.authorDemir, Ufuk
dc.contributor.authorKaratag, Ozan
dc.contributor.authorSencar, Leman
dc.date.accessioned2026-02-03T11:59:40Z
dc.date.available2026-02-03T11:59:40Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: This study aims to investigate the effects of swimming exercise on arthritis severity, radiological joint damage, and leptinrelated molecular changes in experimental rheumatoid arthritis (RA) in rats. Materials and methods: A total of 30 male Wistar rats were randomly assigned to three groups (n=10 per group): Control, Arthritis, and Exercise + Arthritis. Experimental arthritis was induced by a single intradermal injection of Complete Freund's Adjuvant (CFA). The Exercise + Arthritis group underwent a six-week swimming protocol (1 h/day, five days/week), beginning two weeks before arthritis induction and continuing thereafter. Arthritis severity was assessed by visual scoring, radiological analysis, and histopathological evaluation. Plasma concentrations of leptin and matrix metalloproteinases (MMP-1, MMP-3, MMP-8, MMP-13) were measured using enzyme-linked immunosorbent assay (ELISA), and leptin receptor expression in paw tissues was analyzed immunohistochemically. Results: The Exercise + Arthritis group exhibited significantly lower visual arthritis scores (p=0.002), reduced ankle swelling (p<0.001), and decreased cartilage and bone damage radiologically (p=0.045) compared to the Arthritis group. Histopathological evaluation revealed that swimming exercise markedly attenuated inflammatory cell infiltration, pannus formation, and bone resorption. Although plasma leptin and MMP levels did not differ between the groups (p>0.05), leptin receptor expression, considered to be associated with joint damage, was found to be significantly lower in the Exercise + Arthritis group (p=0.009). Swimming exercise reduced arthritis severity and joint damage. Conclusion: Moderate-intensity swimming exerts protective, anti-inflammatory effects in experimental RA by reducing inflammation and preserving joint structure in rats, possibly through modulating leptin receptor expression and inflammatory pathways. Although regular swimming may serve as a useful adjunct to slow disease progression and joint damage in RA in rats, the translational relevance of these results remains uncertain in humans.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) [120S402]
dc.description.sponsorshipÇanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit [TSA-2022-3813]
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkiye (TUBITAK) (Project No: 120S402) and the Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit (Project No: TSA-2022-3813) .
dc.identifier.doi10.5606/tftrd.2025.17494
dc.identifier.endpage606
dc.identifier.issn2587-1250
dc.identifier.issue4
dc.identifier.scopus2-s2.0-105025906868
dc.identifier.scopusqualityQ2
dc.identifier.startpage595
dc.identifier.urihttps://doi.org/10.5606/tftrd.2025.17494
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34360
dc.identifier.volume71
dc.identifier.wosWOS:001632870800018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurkish Journal of Physical Medicine and Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectInflammation
dc.subjectleptin
dc.subjectmatrix metalloproteinase
dc.subjectrat model
dc.subjectrheumatoid arthritis
dc.subjectswimming exercise
dc.titleProtective effects of swimming exercise on experimental rheumatoid arthritis in rats through modulation of leptin receptor expression and inflammation
dc.typeArticle

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