Development of Ductile-Sticky Bone Fillers from Biodegradable Hydrolyzed Wool-Keratin and Silk Fibroin
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In the present study, a method is proposed for preparing novel ductile-sticky materials that can be used as bone void fillers using hydrolyzed wool-keratin (WK) and silk fibroin (SF). This methodology uses citric acid as a cross-linking agent in preparing keratin paste (KP) owing to its non-toxicity and plasticizing properties. The Keratin paste-silk fibroin structure (KPSF) is obtained by adding SF, which possesses biocompatible and superior mechanical properties. Methanol treatment is employed on the KPSF mixture to convert the Silk I structure in the SF to Silk II, resulting in a water-insoluble and tightly packed proteinaceous structure. The physicochemical properties of both bioscaffolds are investigated and discussed in detail by comparison. Based on the findings, the presence of SF in the KPSF structure contributed to properties such as flexibility and porosity. In ovo CAM analysis reveals that both materials exhibit proangiogenic properties and are biocompatible. KP and KPSF bioscaffolds can be converted into ductile-sticky forms by adding water. It believes that these forms can easily apply to bone defect areas, particularly cavitary bone defects. Furthermore, KPSF bioscaffolds, with better mechanical properties, can be considered candidates for use in non-load-bearing bone tissue engineering applications. This study introduces a strategy using citric acid as a crosslinker and plasticizer to create ductile-sticky Keratin Paste (KP) and Keratin paste-silk fibroin (KPSF) bone fillers. This study proposes that moldable ductile-sticky KP and KPSF materials are suitable for cavitary bone defects, while lyophilized forms of KPSF bioscaffolds, offering flexibility and robustness, are ideal for non-load-bearing bone tissue engineering applications. image
Açıklama
Anahtar Kelimeler
bone filler materials, bone tissue engineering, Hydrolyzed wool-keratin, paste, silk fibroin
Kaynak
Macromolecular Materials and Engineering
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
309
Sayı
11
