Development of Ductile-Sticky Bone Fillers from Biodegradable Hydrolyzed Wool-Keratin and Silk Fibroin

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dc.authoridARSLAN, Yavuz Emre/0000-0003-3445-1814
dc.authoridSezgin Arslan, Tugba/0000-0003-2547-6120
dc.contributor.authorBekar, Serife
dc.contributor.authorArslan, Tugba Sezgin
dc.contributor.authorArslan, Yavuz Emre
dc.date.accessioned2025-01-27T20:20:44Z
dc.date.available2025-01-27T20:20:44Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn the present study, a method is proposed for preparing novel ductile-sticky materials that can be used as bone void fillers using hydrolyzed wool-keratin (WK) and silk fibroin (SF). This methodology uses citric acid as a cross-linking agent in preparing keratin paste (KP) owing to its non-toxicity and plasticizing properties. The Keratin paste-silk fibroin structure (KPSF) is obtained by adding SF, which possesses biocompatible and superior mechanical properties. Methanol treatment is employed on the KPSF mixture to convert the Silk I structure in the SF to Silk II, resulting in a water-insoluble and tightly packed proteinaceous structure. The physicochemical properties of both bioscaffolds are investigated and discussed in detail by comparison. Based on the findings, the presence of SF in the KPSF structure contributed to properties such as flexibility and porosity. In ovo CAM analysis reveals that both materials exhibit proangiogenic properties and are biocompatible. KP and KPSF bioscaffolds can be converted into ductile-sticky forms by adding water. It believes that these forms can easily apply to bone defect areas, particularly cavitary bone defects. Furthermore, KPSF bioscaffolds, with better mechanical properties, can be considered candidates for use in non-load-bearing bone tissue engineering applications. This study introduces a strategy using citric acid as a crosslinker and plasticizer to create ductile-sticky Keratin Paste (KP) and Keratin paste-silk fibroin (KPSF) bone fillers. This study proposes that moldable ductile-sticky KP and KPSF materials are suitable for cavitary bone defects, while lyophilized forms of KPSF bioscaffolds, offering flexibility and robustness, are ideal for non-load-bearing bone tissue engineering applications. image
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit [FYL-2022-3981]
dc.description.sponsorshipThe authors thank the Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit (Project ID: FYL-2022-3981) for the financial support and acknowledge the Canakkale Onsekiz Mart University Science and Technology Application and Research Center (COBILTUM) providing facilities for analysis. The authors also thank Mr. Yuecel Okatali (MER-TER Medical, Eski & scedil;ehir, Tuerkiye) for the HC staining.
dc.identifier.doi10.1002/mame.202400144
dc.identifier.issn1438-7492
dc.identifier.issn1439-2054
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85199050688
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/mame.202400144
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21800
dc.identifier.volume309
dc.identifier.wosWOS:001273603100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofMacromolecular Materials and Engineering
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectbone filler materials
dc.subjectbone tissue engineering
dc.subjectHydrolyzed wool-keratin
dc.subjectpaste
dc.subjectsilk fibroin
dc.titleDevelopment of Ductile-Sticky Bone Fillers from Biodegradable Hydrolyzed Wool-Keratin and Silk Fibroin
dc.typeArticle

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