One-step fabrication of biocompatible carboxymethyl cellulose polymeric particles for drug delivery systems

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridBütün Şengel, Sultan / 0000-0001-7036-2224
dc.authoridErduğan, Hüseyin / 0000-0002-7047-6640
dc.contributor.authorBütün, Sultan
dc.contributor.authorİnce, Fatma Gül
dc.contributor.authorErduğan, Hüseyin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:50:00Z
dc.date.available2025-01-27T20:50:00Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCarboxymethyl cellulose (CMC) particles were synthesized in one step employing inverse micelle microemulsion polymerization using divinyl sulfone as crosslinking agent. These synthesized particles were further modified and demonstrated as drug delivery system. Acyclovir was chosen as the model drug. The synthesized CMC particles were made magnetic responsive by encasing independently prepared magnetic ferrite particles (Fe(3)O(4)) in CMC polymeric particles during the synthesis as magnetic-CMC (m-CMC). The particles were characterized by using dynamic light scattering (DLS), zeta potential measurements (ZP). FT-IR spectroscopy, scanning electron microscopy (SEM) and thermogravimetric analyzer (TGA). The synthesized particles have wide size distribution ranging from 100 to 10,000 nm. The further modification of CMC and magnetic Fe(3)O(4) containing CMC polymeric particles crosslinked at different ratios was performed successfully by introducing new functional groups to the CMC networks. It was determined that these particles obtained from the natural CMC polymers have a potential range of application as drug and targeted drug delivery system in biomedical field. (C) 2011 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipCanakkale Onsekiz Mart University [2010/123]; Turkish Academy of Science (TUBA)
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University (2010/123). Also, N. Sahiner greatly acknowledges the Turkish Academy of Science (TUBA) for the financial support under TUBA-GEGIP 2008 program.
dc.identifier.doi10.1016/j.carbpol.2011.05.001
dc.identifier.endpage643
dc.identifier.issn0144-8617
dc.identifier.issue2
dc.identifier.scopus2-s2.0-79960565696
dc.identifier.scopusqualityQ1
dc.identifier.startpage636
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2011.05.001
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25380
dc.identifier.volume86
dc.identifier.wosWOS:000294187400032
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMicroemulsion polymerization
dc.subjectCellulose drug delivery system
dc.subjectCMC particles
dc.subjectMagnetic-CMC
dc.subjectBiocompatible and biodegradable
dc.subjectBiomedical application
dc.titleOne-step fabrication of biocompatible carboxymethyl cellulose polymeric particles for drug delivery systems
dc.typeArticle

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