One-step fabrication of biocompatible carboxymethyl cellulose polymeric particles for drug delivery systems
Yükleniyor...
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Carboxymethyl cellulose (CMC) particles were synthesized in one step employing inverse micelle microemulsion polymerization using divinyl sulfone as crosslinking agent. These synthesized particles were further modified and demonstrated as drug delivery system. Acyclovir was chosen as the model drug. The synthesized CMC particles were made magnetic responsive by encasing independently prepared magnetic ferrite particles (Fe(3)O(4)) in CMC polymeric particles during the synthesis as magnetic-CMC (m-CMC). The particles were characterized by using dynamic light scattering (DLS), zeta potential measurements (ZP). FT-IR spectroscopy, scanning electron microscopy (SEM) and thermogravimetric analyzer (TGA). The synthesized particles have wide size distribution ranging from 100 to 10,000 nm. The further modification of CMC and magnetic Fe(3)O(4) containing CMC polymeric particles crosslinked at different ratios was performed successfully by introducing new functional groups to the CMC networks. It was determined that these particles obtained from the natural CMC polymers have a potential range of application as drug and targeted drug delivery system in biomedical field. (C) 2011 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Microemulsion polymerization, Cellulose drug delivery system, CMC particles, Magnetic-CMC, Biocompatible and biodegradable, Biomedical application
Kaynak
Carbohydrate Polymers
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
86
Sayı
2
