Investigation of the probiotic effects of Lactobacillus sakei 2-3 and Candida zeylanoides Y12-3 strains in rainbow trout (Oncorhynchus mykiss, Walbaum 1792)

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dc.authoridYılmaz, Sevdan / 0000-0002-4809-5809
dc.authoridGürkan, Mert / 0000-0001-7861-3999
dc.contributor.authorTaha, Mohanad Dheyaa
dc.contributor.authorDidinen, Behire Işıl
dc.contributor.authorYılmaz, Sevdan
dc.contributor.authorGürkan, Mert
dc.contributor.authorKenanoğlu, Osman Nezih
dc.date.accessioned2025-05-29T02:58:06Z
dc.date.available2025-05-29T02:58:06Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study aimed to assess individual and combined effects of candidate probiotic strains C. zeylanoides Y12-3 and L. sakei 2-3 on growth, hematological parameters, serum immunological parameters, serum biochemistry, histopathology, histomorphology, expression of immune and antioxidant enzyme genes, and disease resistance against L. garvieae in rainbow trout. The fish were fed four different feeds (control, L. sakei 2-3, C. zeylanoides Y12-3, and L. sakei 2-3 + C. zeylanoides Y12-3) for 60 days. At the end of the experiment, growth parameters, serum glucose levels, serum lysozyme activity, and expression of immune and antioxidant enzyme genes were significantly increased in the probiotic groups. Additionally, triglyceride levels decreased in the probiotic groups compared to the control group, whereas serum ALT levels did not change. The villus width and the number of goblet cells increased in the proximal intestines of the fish in C. zeylanoides and L. sakei + C. zeylanoides groups. L. sakei 2-3 showed higher superoxide anion production, expression of immune genes (IgM, IL-B1, lysozyme, TNF-alpha, HSP70) in the kidney, antioxidant enzyme genes (GPX, GST, SOD) in the liver compared to C. zeylanoides. TNF-alpha, HSP70), and antioxidant enzyme genes (GPX, GST, SOD) compared to C. zeylanoides. L. sakei and the combination of L. sakei + C. zeylanoides provided resistance to L. garvieae compared to the control group. However, C. zeylanoides was similar to the other two probiotic groups regarding disease resistance against L. garvieae. However, histopathological examinations revealed reversible changes in the proximal intestine, anterior kidney, and liver of fish in the C. zeylanoides and L. sakei + C. zeylanoides groups. Hence, future studies are still required to explore the effects of shorter-term use of the C. zeylanoides strain in rainbow trout to prevent undesirable effects on tissues. In brief, the findings, as mentioned above, showed that L. sakei 2-3 and C. zeylanoides Y12-3 could be potential probiotic candidates for use in rainbow trout farming. Moreover, the probiotic effects of both strains on different fish species should also be studied.
dc.description.sponsorshipThis study is supported by TUBITAK (The Scientific and Technological Research Council of Turkey) [123O011]; TUBITAK (The Scientific and Technological Research Council of Turkey); TUBITAK
dc.description.sponsorshipThis study is supported by TUBITAK (The Scientific and Technological Research Council of Turkey) Project with Number 123O011. We would like to thank TUBITAK for its support.
dc.identifier.doi10.1007/s10499-025-01885-1
dc.identifier.issn0967-6120
dc.identifier.issn1573-143X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85219199314
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10499-025-01885-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30277
dc.identifier.volume33
dc.identifier.wosWOS:001435006600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofAquaculture International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectRainbow trout
dc.subjectProbiotic
dc.subjectYeast
dc.subjectLactic acid bacteria
dc.subjectDisease resistance
dc.subjectL. garvieae
dc.titleInvestigation of the probiotic effects of Lactobacillus sakei 2-3 and Candida zeylanoides Y12-3 strains in rainbow trout (Oncorhynchus mykiss, Walbaum 1792)
dc.typeArticle

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