A disposable biosensing system for analysis of CA125 in real human serum samples

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dc.authoridAfşar, Meltem / 0000-0002-4551-756X
dc.authoridVural, Berfin / 0000-0003-2752-9708
dc.authoridSezgintürk, Mustafa Kemal / 0000-0003-3042-1087
dc.contributor.authorAfşar, Meltem
dc.contributor.authorVural, Berfin
dc.contributor.authorBilgi Kamaç, Melike
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.date.accessioned2026-02-03T12:03:23Z
dc.date.available2026-02-03T12:03:23Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSeveral biomarkers have been developed to track the development of ovarian cancer and identify the illness at an early stage. A promising development for ovarian cancer is using cancer antigen 125 (CA125). The objective of this work is to identify the CA125 marker by utilizing an indium tin oxide polyethylene electrode. The advantage of the designed biosensor is that it is very cheap, disposable, practical, and easy to use. The necessary parameters for the developed biosensor have been optimized in detail. Repeatability, reproducibility, regeneration, storage, and selectivity studies have been completed to characterize the proposed biosensor. Electrochemical impedance spectroscopy and cyclic voltammetry techniques were used for all experimental investigations of the proposed biosensor. The immunosensor offers a large linear detection range (0.01-100 pg/mL). Moreover, this developed sensor has a 0.018 pg/mL limit of detection and a 0.06 pg/mL limit of quantification. The high accuracy of this biosensor was observed in five commercial human serums.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK) through the 1001-Scientific and Technological Research Projects Support Program [118R030]
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK) through the 1001-Scientific and Technological Research Projects Support Program (project number: 118R030).
dc.identifier.doi10.55730/1300-0527.3748
dc.identifier.issn1300-0527
dc.identifier.issue4
dc.identifier.scopus2-s2.0-105015560777
dc.identifier.scopusqualityQ3
dc.identifier.trdizinid1334156
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3748
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1334156
dc.identifier.urihttps://hdl.handle.net/20.500.12428/35059
dc.identifier.volume49
dc.identifier.wosWOS:001561452200010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectCA125
dc.subjectbiosensor
dc.subjectovarian cancer
dc.subjectp-benzoquinone
dc.titleA disposable biosensing system for analysis of CA125 in real human serum samples
dc.typeArticle

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