Protective effect of Spirulina in the ovary of rats against Doxorubicin toxicity

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dc.authoridOZTURK, Samil/0000-0002-9435-8139
dc.contributor.authorOzturk, Samil
dc.contributor.authorIrkin, Latife Ceyda
dc.date.accessioned2025-01-27T20:29:50Z
dc.date.available2025-01-27T20:29:50Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDoxorubicin (Dox) is an anti-cancer agent used of ovarian, breast, liver, lung cancers and solid tumors such as leukemia and lymphoma treatment. However, since it is an antineoplastic agent with a high toxic effect, it causes toxicity on many organs and tissues in the organism. Spirulina spp. (SP) contains phytopigments such as beta- carotene, tocopherols and xanthophylls and is a natural source of vitamin A as well as its anticarcinogenic effect. For these reasons, this study was planned to experimentally reveal the antioxidant and protective effects of SP on Dox-induced reproductive toxicity in female rats. In the study, histopathological evaluation was performed after Hematoxylin-Eosin staining in female rats with Dox toxicity. The distribution of GSK-3 beta for cell proliferation, HIF-1 alpha for oxidative stress and VEGF for vascularization were evaluated. TUNEL staining was performed to determine apoptosis. It was determined that SP prevented tissue damage on the ovarian tissue of rats with Dox toxicity, and this positive effect was achieved through factors such as oxidative stress (HIF-1 alpha), vascularization (VEGF) and inhibition of cell death (Apoptosis). It has been observed that SP treatment to be applied after chemotherapy is effective in protecting both the developing follicles and the primordial follicle pool.
dc.description.sponsorshipCanakkale Onsekiz Mart University, Scientific Research Project Unit [FBA 2021-3970]
dc.description.sponsorshipThis work was supported by the Canakkale Onsekiz Mart University, Scientific Research Project Unit (FBA 2021-3970).
dc.identifier.doi10.52973/rcfcv-e34315
dc.identifier.issn0798-2259
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85185461693
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.52973/rcfcv-e34315
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23049
dc.identifier.volume34
dc.identifier.wosWOS:001179774400022
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Zulia, Facultad Ciencias Veterinarias
dc.relation.ispartofRevista Cientifica-Facultad De Ciencias Veterinarias
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSpirulina spp.
dc.subjectapoptozis
dc.subjectovary
dc.subjectinfertility
dc.subjectdoxorubicin
dc.titleProtective effect of Spirulina in the ovary of rats against Doxorubicin toxicity
dc.title.alternativeEfecto protector de la espirulina en el ovario de ratas contra la toxicidad de la Doxorrubicina
dc.typeArticle

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