Investigation of hepatotoxic effect of bryophytes (Homalothecium sericeum (HEDW) Schimp.) on rat liver

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dc.authorid0000-0002-9435-8139en_US
dc.authorid0000-0002-3554-1881en_US
dc.authorscopusid57193693689en_US
dc.authorscopusid55665644200en_US
dc.authorwosid-en_US
dc.authorwosidCAI-2940-2022en_US
dc.contributor.authorÖzturk, Şamil
dc.contributor.authorYayıntaş, Özlem Tonguç
dc.date.accessioned2022-09-21T12:35:17Z
dc.date.available2022-09-21T12:35:17Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractNo evidence has been found to determine whether moss extract affects fibrotic, inflammatory, apoptotic and tissue homeostasis for tissue regeneration on rat's liver tissue. In our study, 1 ml of distilled water (Group I), and 50 mg/kg (Group II), 100 mg/kg (Group III), 300 mg/kg (Group IV), 500 mg/kg (Group V) for 30 days' doses of moss and by gavage of a total of 30 female rats in liver tissue due to the increase in the dose of moss histopathology was revealed. Also, immunohistochemical staining was performed to determine the immunoreactivity of transcription factor nuclear factor Kappa-B (NF-ΚB), tumor necrosis factor (TNF-α), which regulates inflammation and immune response, and TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) for the assessment of the apoptotic process. The stained tissue samples were evaluated with the image analysis system under the research microscope and One-way ANOVA, Tukey test, which is one of the nonparametric tests, was used to determine the differences between the groups statistically and the results were evaluated according to p<0.05. We found that liver damage increased due to the increased dose of moss species used in the experiment. At the same time, antioxidant activity was increased, and apoptosis was increased. Considering these results, it was concluded that algae extract would have anticancer properties and could be used in the pharmaceutical industry.en_US
dc.identifier.citationOzturk, S., & Yayintas, O. T. (2021). Investigation of hepatotoxic effect of bryophytes (homalothecium sericeum (HEDW) schimp.) on rat liver. Fresenius Environmental Bulletin, 30(2), 1134-1146.en_US
dc.identifier.endpage1146en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85101587012
dc.identifier.startpage1134en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3735
dc.identifier.volume30en_US
dc.identifier.wosWOS:000626629900033
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzturk, Şamil
dc.institutionauthorYayıntaş, Özlem Tonguç
dc.language.isoen
dc.publisherParlar Scientific Publicationsen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectBryophytesen_US
dc.subjectImmimohistochemistryen_US
dc.subjectNF-ΚBen_US
dc.subjectTNF-αen_US
dc.subjectTUNELen_US
dc.titleInvestigation of hepatotoxic effect of bryophytes (Homalothecium sericeum (HEDW) Schimp.) on rat liver
dc.typeArticle

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