Pan-Mitogenomics Approach Discovers Diversity and Dynamism in the Prominent Brown Rot Fungal Pathogens

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dc.authorid-en_US
dc.authorid0000-0003-0791-975Xen_US
dc.authorscopusid57217277770en_US
dc.authorscopusid35389412700en_US
dc.authorwosid-en_US
dc.authorwosidM-2853-2014en_US
dc.contributor.authorYıldız, Gözde
dc.contributor.authorÖzkılınç, Hilal
dc.date.accessioned2023-07-11T10:28:31Z
dc.date.available2023-07-11T10:28:31Z
dc.date.issued2021en_US
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Biyomoleküler Bilimler Ana Bilim Dalı
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractMonilinia fructicola and Monilinia laxa species are the most destructive and economically devastating fungal plant pathogens causing brown rot disease on stone and pome fruits worldwide. Mitochondrial genomes (mitogenomes) play critical roles influencing the mechanisms and directions of the evolution of fungal pathogens. The pan-mitogenomics approach predicts core and accessory regions of the mitochondrial genomes and explains the gain or loss of variation within and between species. The present study is a fungal pan-mitogenome of M. fructicola (N = 8) and M. laxa (N = 8) species. The completely sequenced and annotated mitogenomes showed high variability in size within and between the species. The mitogenomes of M. laxa were larger, ranging from 178,351 to 179,780bp, than the mitogenomes of M. fructicola, ranging from 158,607 to 167,838bp. However, size variation within the species showed that M. fructicola isolates were more variable in the size range than M. laxa isolates. All the mitogenomes included conserved mitochondrial genes, as well as variable regions including different mobile introns encoding homing endonucleases or maturase, non-coding introns, and repetitive elements. The linear model analysis supported the hypothesis that the mitogenome size expansion is due to presence of variable (accessory) regions. Gene synteny was mostly conserved among all samples, with the exception for order of the rps3 in the mitogenome of one isolate. The mitogenomes presented AT richness; however, A/T and G/C skew varied among the mitochondrial genes. The purifying selection was detected in almost all the protein-coding genes (PCGs) between the species. However, cytochrome b was the only gene showing a positive selection signal among the total samples. Combined datasets of amino acid sequences of 14 core mitochondrial PCGs and rps3 obtained from this study together with published mitochondrial genome sequences from some other species from Heliotales were used to infer a maximum likelihood (ML) phylogenetic tree. ML tree indicated that both Monilinia species highly diverged from each other as well as some other fungal species from the same order. Mitogenomes harbor much information about the evolution of fungal plant pathogens, which could be useful to predict pathogenic life strategies.en_US
dc.identifier.citationYıldız, G., & Özkılınç, H. (2021). Pan-mitogenomics approach discovers diversity and dynamism in the prominent brown rot fungal pathogens. Frontiers in Microbiology, 12 doi:10.3389/fmicb.2021.647989en_US
dc.identifier.doi10.3389/fmicb.2021.647989
dc.identifier.issn1664-302X
dc.identifier.pmid34054750
dc.identifier.scopus2-s2.0-85107024179
dc.identifier.urihttps://doi.org/10.3389/fmicb.2021.647989
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4366
dc.identifier.volume12en_US
dc.identifier.wosWOS:000654014600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldız, Gözde
dc.institutionauthorÖzkılınç, Hilal
dc.language.isoen
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/217Z134
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBrown roten_US
dc.subjectEvolutionen_US
dc.subjectMitogenomeen_US
dc.subjectMonilinia speciesen_US
dc.subjectPan-mitogenomicsen_US
dc.titlePan-Mitogenomics Approach Discovers Diversity and Dynamism in the Prominent Brown Rot Fungal Pathogens
dc.typeArticle

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