Investigation of Drug Release Behavior of Cyclomatrix Polyphosphazene Microparticles Decorated with Gold and Silver Nanoparticles

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dc.authorid-en_US
dc.authorid0000-0002-4184-7801en_US
dc.authorscopusid56053270500en_US
dc.authorscopusid35102910700en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorDilek, Esra
dc.contributor.authorÖzay, Hava
dc.date.accessioned2024-02-10T06:54:03Z
dc.date.available2024-02-10T06:54:03Z
dc.date.issued2024en_US
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Kimya Ana Bilim Dalı
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.description.abstractIn this study, p(CTP-co-MMCA) microparticles, a novel cyclomatrix polyphosphazene, were synthesized. Among the p(CTP-co-MMCA) polymeric structures, p(CTP-co-MMCA) (1 : 3) with a high surface amine group was found to be in the form of microparticles after detailed structural and morphological characterization. These microparticles were modified with Au0 and Ag0 nanoparticles using two different green reductants. The antimicrobial activities of p(CTP-co-MMCA) microparticles and their Au0 and Ag0 composites against P.Aeruginosa ATCC 27853, S.Aureus ATCC 6538 and C.Albicans were investigated. Metal composites were found to have better antimicrobial activity. Cyclomatrix p(CTP-co-MMCA) microparticles with antimicrobial properties and their Au0 and Ag0 composites were also used for the release of Ceftriaxone sodium and RNA. Cyclomatrix p(CTP-co-MMCA) microparticles and its Au0 and Ag0 composites retained 48.21±5.34 mg/g, 49.36±6.95 mg/g and 23.95±6.45 mg/g ceftriaxone sodium, respectively, while they retained 79.15±6.85 mg/g, 47.49±6.24 mg/g and 57.47±9.48 mg/g RNA, respectively. Release studies revealed that the presence of Au0 and Ag0 nanoparticles imparted a slower release behavior to p(CTP-co-MMCA) microparticles. The release studies revealed that the presence of Au0 and Ag0 nanoparticles imparted a slower release behavior to the p(CTP-co-MMCA) microparticles.en_US
dc.identifier.citationDilek, E., & Özay, H. (2024). Investigation of Drug Release Behavior of Cyclomatrix Polyphosphazene Microparticles Decorated with Gold and Silver Nanoparticles. ChemistrySelect, 9(1). https://doi.org/10.1002/slct.202304583en_US
dc.identifier.doi10.1002/slct.202304583
dc.identifier.issn2365-6549
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85181190201
dc.identifier.urihttps://doi.org/10.1002/slct.202304583
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5634
dc.identifier.volume9en_US
dc.identifier.wosWOS:001134992700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDilek, Esra
dc.institutionauthorÖzay, Hava
dc.language.isoen
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistrySelecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectCyclomatrixen_US
dc.subjectDrug releaseen_US
dc.subjectGold nanoparticleen_US
dc.subjectPhosphazeneen_US
dc.titleInvestigation of Drug Release Behavior of Cyclomatrix Polyphosphazene Microparticles Decorated with Gold and Silver Nanoparticles
dc.typeArticle

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