Investigation of Drug Release Behavior of Cyclomatrix Polyphosphazene Microparticles Decorated with Gold and Silver Nanoparticles
Yükleniyor...
Dosyalar
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, p(CTP-co-MMCA) microparticles, a novel cyclomatrix polyphosphazene, were synthesized. Among the p(CTP-co-MMCA) polymeric structures, p(CTP-co-MMCA) (1 : 3) with a high surface amine group was found to be in the form of microparticles after detailed structural and morphological characterization. These microparticles were modified with Au0 and Ag0 nanoparticles using two different green reductants. The antimicrobial activities of p(CTP-co-MMCA) microparticles and their Au0 and Ag0 composites against P.Aeruginosa ATCC 27853, S.Aureus ATCC 6538 and C.Albicans were investigated. Metal composites were found to have better antimicrobial activity. Cyclomatrix p(CTP-co-MMCA) microparticles with antimicrobial properties and their Au0 and Ag0 composites were also used for the release of Ceftriaxone sodium and RNA. Cyclomatrix p(CTP-co-MMCA) microparticles and its Au0 and Ag0 composites retained 48.21±5.34 mg/g, 49.36±6.95 mg/g and 23.95±6.45 mg/g ceftriaxone sodium, respectively, while they retained 79.15±6.85 mg/g, 47.49±6.24 mg/g and 57.47±9.48 mg/g RNA, respectively. Release studies revealed that the presence of Au0 and Ag0 nanoparticles imparted a slower release behavior to p(CTP-co-MMCA) microparticles. The release studies revealed that the presence of Au0 and Ag0 nanoparticles imparted a slower release behavior to the p(CTP-co-MMCA) microparticles.
Açıklama
Anahtar Kelimeler
Antimicrobial, Cyclomatrix, Drug release, Gold nanoparticle, Phosphazene
Kaynak
ChemistrySelect
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
9
Sayı
1
Künye
Dilek, E., & Özay, H. (2024). Investigation of Drug Release Behavior of Cyclomatrix Polyphosphazene Microparticles Decorated with Gold and Silver Nanoparticles. ChemistrySelect, 9(1). https://doi.org/10.1002/slct.202304583
