Histopathological effects of Montivipera xanthina venom on rats

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dc.contributor.authorTopyildiz, Huseyin
dc.contributor.authorHayretdag, Sibel
dc.date.accessioned2025-01-27T20:58:24Z
dc.date.available2025-01-27T20:58:24Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, the histopathological changes caused by Montivipera xanthina venom to rat skin, skeletal muscle, and liver tissue were analysed by light microscope. The venom (approximately 2.85 mg/kg) was injected intramuscularly into the gastrocnemius muscle of the rats. The animals were dissected 1, 3, and 6 h after the injection time, and tissue samples were taken. Sections 5 pm thick were taken from paraffin blocks of tissue samples, and the sections were stained with haematoxylin and eosin in order to facilitate examination by light microscope. Examinations showed no damage to the epidermis layer of skin. However, damage to the dermis layer, including oedema, haemorrhage, local bleeding, rare inflammatory cells, strong cell infiltration with mixed characteristics, inflammation around the veins, and fat necrosis, was detected. The damage observed in muscular tissue was myonecrosis, mixed character cell infiltration, haemorrhage, and the formation of inclusion on myofibrils. The liver tissue revealed sinusoidal congestion and hepatocellular degeneration.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Project Commission
dc.description.sponsorshipThis study was supported by the Canakkale Onsekiz Mart University Scientific Research Project Commission (2007/15 project).
dc.identifier.doi10.3906/zoo-1007-23
dc.identifier.endpage525
dc.identifier.issn1300-0179
dc.identifier.issn1303-6114
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84862248160
dc.identifier.scopusqualityQ2
dc.identifier.startpage517
dc.identifier.trdizinid138927
dc.identifier.urihttps://doi.org/10.3906/zoo-1007-23
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/138927
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26695
dc.identifier.volume36
dc.identifier.wosWOS:000307484500012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Zoology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectMontivipera xanthina
dc.subjecthistopathology
dc.subjectvenom
dc.subjectskin
dc.subjectskeletal muscle
dc.subjectliver
dc.titleHistopathological effects of Montivipera xanthina venom on rats
dc.title.alternativeSıçanlarda Montivipera xanthina venomunun histopatolojik etkileri
dc.typeArticle

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