Histopathological effects of Montivipera xanthina venom on rats
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Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technological Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, the histopathological changes caused by Montivipera xanthina venom to rat skin, skeletal muscle, and liver tissue were analysed by light microscope. The venom (approximately 2.85 mg/kg) was injected intramuscularly into the gastrocnemius muscle of the rats. The animals were dissected 1, 3, and 6 h after the injection time, and tissue samples were taken. Sections 5 pm thick were taken from paraffin blocks of tissue samples, and the sections were stained with haematoxylin and eosin in order to facilitate examination by light microscope. Examinations showed no damage to the epidermis layer of skin. However, damage to the dermis layer, including oedema, haemorrhage, local bleeding, rare inflammatory cells, strong cell infiltration with mixed characteristics, inflammation around the veins, and fat necrosis, was detected. The damage observed in muscular tissue was myonecrosis, mixed character cell infiltration, haemorrhage, and the formation of inclusion on myofibrils. The liver tissue revealed sinusoidal congestion and hepatocellular degeneration.
Açıklama
Anahtar Kelimeler
Montivipera xanthina, histopathology, venom, skin, skeletal muscle, liver
Kaynak
Turkish Journal of Zoology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
36
Sayı
4
