Modulation of Gut Microbiota Using VSL#3 and Its Impact on Aortic Parameters in a Rat Model

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dc.contributor.authorAltun, Mehzat
dc.contributor.authorKucuk, Ugur
dc.contributor.authorYildirim, Nuray
dc.date.accessioned2026-02-03T12:00:24Z
dc.date.available2026-02-03T12:00:24Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The increase in aortic stiffness is a significant parameter of cardiovascular diseases (CVDs), posing a substantial global health challenge and economic burden. The gut microbiota and its homeostasis, directly and indirectly, influence CVD. This study investigated the extent to which alterations in the gut microbiota can affect aortic parameters in a rat model through the administration of VSL#3. Methods: Twelve male Wistar rats were divided into VSL#3-treated and control groups. Cardiac function, aortic systolic, and diastolic values were assessed via echocardiography on day 0 and day 42, and fecal specimens were simultaneously collected from each rat. The formation and composition of the gut microbial flora were profiled using 16S Results: Differences in bacterial density, as indicated by Chao analysis, exhibited statistical significance (P = .037) between the 2 groups. Additionally, in the VSL#3-treated group, significant improvements were observed in aortic systolic and diastolic diameters, as well as in aortic strain parameters, compared to the control group. Conclusion: This research highlights the potential of gut microbiome modulation, specifically through VSL#3 administration, as a promising strategy to improve aortic parameters, suggesting a novel avenue for cardiovascular health interventions.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Unit [TSA-2022-4196]
dc.description.sponsorshipThis study was supported by the Canakkale Onsekiz Mart University Scientific Research Projects Unit (Project ID: TSA-2022-4196) .
dc.identifier.doi10.14744/AnatolJCardiol.2025.5048
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue6
dc.identifier.pmid40114628
dc.identifier.scopus2-s2.0-105008334936
dc.identifier.scopusqualityQ3
dc.identifier.trdizinid1360666
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2025.5048
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1360666
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34600
dc.identifier.volume29
dc.identifier.wosWOS:001509242400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectrDNA
dc.subjectaortic stiffness
dc.subjectmetagenome
dc.subjectprobiotic
dc.titleModulation of Gut Microbiota Using VSL#3 and Its Impact on Aortic Parameters in a Rat Model
dc.typeArticle

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