Effects of Pleurotus Eryngii (DC.) Quél. Mushroom Extracts on Cell Proliferation in Breast and Colon Cancer Cell Lines

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dc.contributor.authorÖnder, Ferah Cömert
dc.contributor.authorDavutlar, Gülce
dc.contributor.authorÖnder, Alper
dc.contributor.authorAllı, Hakan
dc.contributor.authorAy, Mehmet
dc.date.accessioned2025-01-27T19:28:46Z
dc.date.available2025-01-27T19:28:46Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study was aimed to collect Pleurotus eryngii (DC.) Quél. edible/medicinal mushroom from Çanakkale/Kumkale and to evaluate the antiproliferative effects of alcoholic extracts on breast and colon cancer cell lines. For this purpose, the Soxhlet method prepared methanol and ethanol:H2O (70:30) extracts by gradually increasing solvent polarities. Then, breast (MDA-MB-231, BT-549, BT-20, MCF-7) and colon (HT-29) cancer cell lines were treated with the extracts in increasing concentrations (0.05-0.5 mg/mL) for 48 h. In conclusion, methanol and aqueous ethanol extracts exhibited significant antiproliferative effects in cancer cell lines, according to the MTT assay. The cell viability in the triple-negative breast cancer (TNBC) MDA-MB-231 cell line was highly decreased by methanol extract at a very low concentration (0.1 mg/mL). Furthermore, methanol extract at 0.3 mg/mL reduced the percentage of cell viability in the HT-29 cell line. Aqueous ethanol extract showed antiproliferative activity in breast and colon cancer cell lines at 0.25 mg/mL concentration for 48 h applications. In addition, some bioactive components such as 4-hydroxy flavone, chrysin, and tannic acid of aqueous ethanol extract have been determined by High-Performance Liquid Chromatography (HPLC) analysis. As a result, this study may increase interest in the studies on the anti-cancer activities and the mechanisms of P. eryngii mushroom.
dc.identifier.doi10.28979/jarnas.1499726
dc.identifier.endpage668
dc.identifier.issn2757-5195
dc.identifier.issue3
dc.identifier.startpage659
dc.identifier.trdizinid1267914
dc.identifier.urihttps://doi.org/10.28979/jarnas.1499726
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1267914
dc.identifier.urihttps://hdl.handle.net/20.500.12428/15882
dc.identifier.volume10
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of advanced research in natural and applied sciences (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectCancer
dc.subjectnatural products
dc.subjectmushroom
dc.subjectantiproliferation
dc.subjectPleurotus eryngii (DC.) Quél.
dc.titleEffects of Pleurotus Eryngii (DC.) Quél. Mushroom Extracts on Cell Proliferation in Breast and Colon Cancer Cell Lines
dc.typeArticle

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