Effects of subchronic exposure to zinc nanoparticles on tissue accumulation, serum biochemistry, and histopathological changes in tilapia (Oreochromis niloticus)

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dc.authoridGurkan, Mert/0000-0001-7861-3999
dc.contributor.authorKaya, Hasan
dc.contributor.authorDuysak, Muge
dc.contributor.authorAkbulut, Mehmet
dc.contributor.authorYılmaz, Sevdan
dc.contributor.authorGuerkan, Mert
dc.contributor.authorArslan, Zikri
dc.contributor.authorDemir, Veysel
dc.date.accessioned2025-01-27T20:20:11Z
dc.date.available2025-01-27T20:20:11Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractZinc nanoparticles (ZnNPs) are among the least investigated NPs and thus their toxicological effects are not known. In this study, tilapia (Oreochromis niloticus) were exposed to 1 and 10 mg/L suspensions of small size (SS, 40-60 nm) and large size (LS, 80-100 nm) ZnNPs for 14 days under semi-static conditions. Total Zn levels in the intestine, liver, kidney, gill, muscle tissue, and brain were measured. Blood serum glucose (GLU), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and lactate dehydrogenase (LDH) were examined to elucidate the physiological disturbances induced by ZnNPs. Organ pathologies were examined for the gills, liver, and kidney to identify injuries associated with exposure. Significant accumulation was observed in the order of intestine, liver, kidney, and gills. Zn levels exhibited time- and concentration-dependent increase in the organs. Accumulation in kidney was also dependent on particle size; NPs SS-ZnNPs were trapped more effectively than LS-ZnNPs. No significant accumulation occurred in the brain (p>0.05) while Zn levels in muscle tissue increased only marginally (p0.05). Significant disturbances were noted in serum GOT and LDH (p<0.05). The GPT levels fluctuated and were not statistically different from those of controls (p>0.05). Histopathological tubular deformations and mononuclear cell infiltrations were observed in kidney sections. In addition, an increase in melano-macrophage aggregation intensity was identified on the 7th day in treatments exposed to LS-ZnNPs. Mononuclear cell infiltrations were identified in liver sections for all treatments. Both ZnNPs caused basal hyperplasia in gill sections. Fusions appeared in the gills after the 7th day in fish treated with 10 mg/L suspensions of SS-ZnNPs. In addition, separations in the secondary lamella epithelia were observed. The results indicated that exposure to ZnNPs could lead to disturbances in blood biochemistry and cause histopathological injuries in the tissues of O. niloticus. (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1213-1225, 2017.
dc.description.sponsorshipTunceli University (Scientific Research Project Fund) [MFTUB013-17]; National Institutes of Health (NIH) RCMI Program [G12RR013459]
dc.description.sponsorshipContract grant sponsor: Tunceli University (Scientific Research Project Fund). Contract grant number: MFTUB013-17. Contract grant sponsor: National Institutes of Health (NIH) RCMI Program. Contract grant number: G12RR013459.
dc.identifier.doi10.1002/tox.22318
dc.identifier.endpage1225
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue4
dc.identifier.pmid27464841
dc.identifier.scopus2-s2.0-84979647960
dc.identifier.scopusqualityQ1
dc.identifier.startpage1213
dc.identifier.urihttps://doi.org/10.1002/tox.22318
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21601
dc.identifier.volume32
dc.identifier.wosWOS:000397534500011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofEnvironmental Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectzinc nanoparticles
dc.subjectaccumulation
dc.subjectserum biochemistry
dc.subjecthistopathology
dc.subjectOreochromis niloticus
dc.titleEffects of subchronic exposure to zinc nanoparticles on tissue accumulation, serum biochemistry, and histopathological changes in tilapia (Oreochromis niloticus)
dc.typeArticle

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